PMID: 2906910Sep 1, 1988Paper

Improvement of inpatient treatment of the alcoholic as a function of neurotransmitter restoration: a pilot study

The International Journal of the Addictions
K BlumJ C Ramsay


We report results of a double-blind evaluation of the nutritional supplement SAAVE for facilitating improvement in a 30-day inpatient alcohol and drug rehabilitation center. SAAVE is uniquely designed to elevate levels of enkephalin(s), serotonin, catecholamines, and GABA, which are believed to be functionally deficient in alcoholics. Twenty-two patients were studied. The SAAVE patients, as compared to the control group (a) had a lower BUD (building up to drink) score, 1 vs 2; (b) required no PRN benzodiazepines, 0% vs 94%; (c) ceased tremoring at 72 h, as compared to 96 h; and (d) had no severe depression on the MMPI, in contrast to 24% of control group. These preliminary data suggest that SAAVE is a valuable adjunct to therapy by aiding the patient's physical adjustment to a detoxified state while facilitating a more positive response to behavioral therapy.


Dec 1, 1987·Alcoholism, Clinical and Experimental Research·C Gianoulakis
Jan 21, 1988·The New England Journal of Medicine·B TabakoffF De Leon-Jones
Feb 1, 1986·The American Journal of Psychiatry·M A Schuckit
Sep 1, 1985·Alcoholism, Clinical and Experimental Research·L BrancheyC S Lieber
May 1, 1985·Journal of Studies on Alcohol·M A Schuckit
Nov 1, 1985·Archives of General Psychiatry·M A Schuckit
Feb 4, 1974·JAMA : the Journal of the American Medical Association·A KalesJ D Kales
May 1, 1981·Pharmacology, Biochemistry, and Behavior·W A Hunt, T K Dalton
Feb 1, 1984·Postgraduate Medicine·M A Schuckit
Dec 16, 1983·Science·M E CharnessI Diamond
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·K BlumJ E Wallace

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Jul 1, 2014·Child and Adolescent Psychiatric Clinics of North America·Charles W Popper
Jun 2, 2016·Neuroscience and Biobehavioral Reviews·D BorsookI Elman
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