Improvement of interaction between PVA and chitosan via magnetite nanoparticles for drug delivery application

International Journal of Biological Macromolecules
Hamidreza ShagholaniMohammad Mousazadeh

Abstract

Magnetite nanoparticles were synthesized by coprecipitation under ultrasonication followed by coating with chitosan. Polyvinyl alcohol (PVA) is then combined with the chitosan that coated the magnetite nanoparticles. The combination occurs by hydrogen binding and ionic cross-linking of the amino and hydroxyl groups of chitosan and PVA respectively. The magnetite nanoparticles have an average size of 10.62 nm that was confirmed by TEM. The VSM measurements showed that nanoparticles were superparamagnetic. The coatings on the core nanoparticles were estimated by AAS and the attachments of coating to the nanoparticles were confirmed by FT-IR analysis. Physicochemical properties of nanoparticles were measured by DLS and zeta potential. Naked magnetite, chitosan and PVA coating have zeta potential of +36.4, +48.1 and -12.5 mV respectively. The unspecific adsorption and interaction between nanoparticles and bovine serum albumin (BSA) were investigated systematically by UV-vis spectroscopy method. The nanoparticles that were modified by PVA present low protein adsorption, which makes them a practical choice for preventing opsonization in clinical application and drug delivery.

References

Mar 9, 2005·Journal of Colloid and Interface Science·Bi-Feng PanHong-Chen Gu
May 5, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Andrew L HookNicolas H Voelcker
Nov 17, 2009·Advanced Drug Delivery Reviews·Omid VeisehMiqin Zhang
Jun 18, 2010·ACS Nano·Eudald CasalsVictor Puntes
Dec 20, 2011·Colloids and Surfaces. B, Biointerfaces·Xuemin LiQiqing Zhang
Mar 29, 2014·Colloids and Surfaces. B, Biointerfaces·Somayeh SadighianMehrdad Hamidi

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Citations

Feb 3, 2016·International Journal of Biological Macromolecules·Yasmeen G Abou El-ReashA Abd Elrazak
Jun 2, 2016·Critical Reviews in Biotechnology·Farnaz AssaAydin Berenjian
Feb 9, 2017·International Journal of Biological Macromolecules·Majid AliabadiArash Yunessnia Lehi
Mar 25, 2018·Scientific Reports·J A Fuentes-GarcíaJ Santoyo-Salazar
Oct 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Gozde S DemirerSeda Kizilel
Jan 1, 2020·International Journal of Molecular Sciences·Elizabeth J BealerXiao Hu
Dec 1, 2020·Journal of Biomedical Materials Research. Part a·Aliaksandr KraskouskiVasilina Lapitskaya
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Hun JeongHong Gun Kim
Jan 10, 2021·Materials·Kinga MylkieMarta Ziegler-Borowska
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Magdalena KędzierskaBożena Tyliszczak
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Fiza Ur RehmanSara Qaisar
Feb 24, 2020·International Journal of Biological Macromolecules·Sara AmirnejatM Reza Naimi-Jamal
Jun 24, 2021·Artificial Cells, Nanomedicine, and Biotechnology·Suhailah S Al-JameelAbdulhadi Baykal
Sep 21, 2021·Journal of Biomolecular Structure & Dynamics·Shruti G BhatkalkarShilpee Sachar
Nov 6, 2021·Environmental Technology·Naiara Miotto MeninoRegina F P M Moreira

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