Improvement of ketamine-induced social withdrawal in rats: the role of 5-HT7 receptors

Behavioural Pharmacology
Małgorzata HołujAgnieszka Nikiforuk

Abstract

Social withdrawal, one of the core negative symptoms of schizophrenia, can be modelled in the social interaction (SI) test in rats using N-methyl-D-aspartate receptor glutamate receptor antagonists. We have recently shown that amisulpride, an antipsychotic with a high affinity for serotonin 5-HT7 receptors, reversed ketamine-induced SI deficits in rats. The aim of the present study was to further elucidate the potential involvement of 5-HT7 receptors in the prosocial action of amisulpride. Acute administration of amisulpride (3 mg/kg) and SB-269970 (1 mg/kg), a 5-HT7 receptor antagonist, reversed ketamine-induced social withdrawal, whereas sulpiride (20 or 30 mg/kg) and haloperidol (0.2 mg/kg) were ineffective. The 5-HT7 receptor agonist AS19 (10 mg/kg) abolished the prosocial efficacy of amisulpride (3 mg/kg). The coadministration of an inactive dose of SB-269970 (0.2 mg/kg) showed the prosocial effects of inactive doses of amisulpride (1 mg/kg) and sulpiride (20 mg/kg). The anxiolytic chlordiazepoxide (2.5 mg/kg) and the antidepressant fluoxetine (2.5 mg/kg) were ineffective in reversing ketamine-induced SI deficits. The present study suggests that the antagonism of 5-HT7 receptors may contribute towards the mechanisms underl...Continue Reading

References

Jan 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·P BoyerF Aubin
Feb 2, 2002·The American Journal of Psychiatry·Stefan LeuchtWerner Kissling
Jun 6, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Axel BeckerGisela Grecksch
Jun 7, 2005·Behavioural Brain Research·Georgina S Perez-García, A Meneses
Feb 17, 2006·Schizophrenia Bulletin·Brian KirkpatrickStephen R Marder
Jun 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eliza KorosFrank Sams-Dodd
May 3, 2008·Behavioural Brain Research·Shikha Snigdha, Joanna C Neill
Apr 2, 2009·Psychopharmacology·Atheir I AbbasBryan L Roth
Jul 21, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Craig A EricksonChristopher J McDougle
Sep 18, 2010·Behavioural Pharmacology·Anand GururajanDaniel Thomas Malone
May 12, 2011·The Journal of Pharmacology and Experimental Therapeutics·M HoriguchiH Y Meltzer
Mar 15, 2012·Neuroreport·Mei HuangHerbert Y Meltzer
May 9, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ben A ChindoKarniyus S Gamaniel
Apr 23, 2013·Behavioural Brain Research·Agnieszka Nikiforuk, Piotr Popik
Apr 25, 2013·CNS Neuroscience & Therapeutics·Bernat KocsisMihaly Hajos
Jun 4, 2013·Biological Psychiatry·John H KrystalRonald S Duman
Aug 14, 2013·Schizophrenia Research·Celso ArangoStephen R Marder
Nov 21, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Michael C DavisStephen R Marder
Nov 28, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·George FoussiasGary Remington
Nov 30, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Joanna C NeillDominic M Dwyer

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Citations

Apr 5, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lucjan StrekowskiAndrzej J Bojarski
Feb 24, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ashleigh L OsborneKatrina Weston-Green
Aug 22, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Piotr StępnickiAgnieszka A Kaczor
Jun 4, 2017·Neurotoxicity Research·Piotr PopikKinga Sałat
Mar 3, 2021·Cellular and Molecular Neurobiology·Mahsa PourhamzehMohammad Taghi Joghataei
May 17, 2018·Journal of Medicinal Chemistry·Maria N ModicaMarcello Leopoldo

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