Improvement of left ventricular function and cardiovascular neural control after endoventriculoplasty and myocardial revascularization

Cardiovascular Research
L Dalla VecchiaA Malliani

Abstract

To investigate the effects of endoventriculoplasty (EVP) and myocardial revascularization on left ventricular function and on sympathovagal balance modulating sinus node and vasomotor activity, we studied patients with left anterior, septal or anteroseptal ventricular aneurysm, before and after surgery. It has been demonstrated that, compared to the standard aneurismectomy, EVP associated with coronary grafting has a lower operative mortality and improves ventricular function, clinical status and prognosis. We collected pre- and post-operative echocardiographic and angiographic data to determine morphological and hemodynamic changes. The pre- and post-operative neural cardiovascular control was assessed by power spectrum analysis of heart rate and systolic arterial pressure (SAP) variabilities during rest and tilt. As expected, post-operative ventricular function improved significantly: ejection fraction increased from 33 +/- 2 to 46 +/- 3% (p < 0.01) when assessed by echocardiography and from 40 +/- 4 to 55 +/- 5% (p < 0.01) when assessed by angiography; left ventricular end-diastolic pressure fell from 22 +/- 3 to 13 +/- 2 mmHg (p < 0.05). Pre-operatively sympathovagal balance responsiveness was blunted: tilt test did not ind...Continue Reading

Citations

Mar 1, 2005·European Journal of Internal Medicine·Alberto Malliani
Aug 19, 2008·Neuroscience and Biobehavioral Reviews·Nicola MontanoFerdinando Iellamo
Apr 12, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Laura Dalla VecchiaRaffaello Furlan

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