Improvement of long-term survival by cardiac contractility modulation in heart failure patients: A case-control study

International Journal of Cardiology
Ming LiuCheuk-Man Yu

Abstract

Cardiac contractility modulation (CCM) has been shown to be effective in improving symptoms and cardiac function in heart failure (HF). However, there is limited data on the role of CCM on long-term survival, which was explored in the present study. Forty-one consecutive HF patients with left ventricular ejection fraction (EF) <40% received CCM and were followed for approximately 6 years. They were compared with another 41 HF patients who were enrolled into the HF registry in the same period, and had similar age, gender, EF and etiology of HF. The primary end-point was all cause-mortality. This was stratified by EF. Secondary end-points included HF hospitalization, cardiovascular death, and the composite outcome of death or heart failure hospitalization. The CCM and control groups were well balanced for demographic data, medications and baseline left ventricular EF (27 ± 6 vs 27 ± 7%, p=NS). The mean follow-up duration was 75 ± 19 months in the CCM group and 69 ± 17 months in the control group. All-cause mortality was lower in the CCM group than the control group (39% vs. 71%, respectively; Log-rank χ(2)=11.23, p=0.001). Of note, the improvement of all-cause mortality is more dramatic in patients with EF ≥ 25-40% (36% vs. 80%, ...Continue Reading

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May 3, 2008·Journal of the American College of Cardiology·Christian ButterHani N Sabbah
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Citations

Oct 28, 2016·Heart Failure Reviews·Freddy Abi-Samra, David Gutterman
Sep 6, 2017·Herz·K-P KresojaC Tschöpe
Sep 14, 2018·Der Internist·J KuschykI Akin
Feb 15, 2019·Current Heart Failure Reports·James A Mann, William T Abraham
Aug 14, 2019·European Journal of Heart Failure·Christophe LeclercqRaphael Martins
Jul 8, 2017·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·D MüllerK-H Kuck
Dec 22, 2020·Terapevticheskiĭ arkhiv·T M UskachS N Tereshchenko
Apr 4, 2020·JACC. Heart Failure·Emily P Zeitler, William T Abraham
Jul 30, 2021·Expert Review of Medical Devices·Habib Hymie CheraMichael Spinelli

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