Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease.

Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance
Carmen Wing-Sze ChanHung-Fat Tse

Abstract

Recent studies suggested that bone marrow (BM) cell implantation in patients with severe chronic coronary artery disease (CAD) resulted in modest improvement in symptoms and cardiac function. This study sought to investigate the functional changes that occur within the chronic human ischaemic myocardium after direct endomyocardial BM cells implantation by cardiovascular magnetic resonance (CMR). We compared the interval changes of left ventricular ejection fraction (LVEF), myocardial perfusion reserve and the extent of myocardial scar by using late gadolinium enhancement CMR in 12 patients with severe CAD. CMR was performed at baseline and at 6 months after catheter-based direct endomyocardial autologous BM cell (n = 12) injection to viable ischaemic myocardium as guided by electromechanical mapping. In patients randomized to receive BM cell injection, there was significant decrease in percentage area of peri-infarct regions (-23.6%, P = 0.04) and increase in global LVEF (+9.0%, P = 0.02), the percentage of regional wall thickening (+13.1%, P= 0.04) and MPR (+0.25%, P = 0.03) over the target area at 6-months compared with baseline. Direct endomyocardial implantation of autologous BM cells significantly improved global LVEF, reg...Continue Reading

References

Feb 13, 2001·Journal of Magnetic Resonance Imaging : JMRI·J R PantingD J Pennell
Mar 23, 2004·Nature·Kenneth R Chien
Jul 20, 2004·European Radiology·Khaled AlfakihMohan Sivananthan

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Citations

Sep 15, 2011·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Dudley J PennellSanjay K Prasad
Nov 20, 2012·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Dudley J PennellSanjay K Prasad
Jan 31, 2012·Imaging in Medicine·Yingli FuDara L Kraitchman
Jan 11, 2014·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Nicole AzeneDara L Kraitchman
Jul 9, 2011·Ageing Research Reviews·Kai Hong WuBin Zhou
Jul 10, 2013·Journal of cardiology·Vincenzo GrimaldiClaudio Napoli
Dec 25, 2016·The Cochrane Database of Systematic Reviews·Sheila A FisherEnca Martin-Rendon
May 19, 2011·Nature Reviews. Cardiology·Mariann Gyöngyösi, Nabil Dib

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Methods Mentioned

BETA
density gradient centrifugation
saturation recovery

Software Mentioned

CAD
PROTECT
Cinetool

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