PMID: 9448320Mar 14, 1998Paper

Improvement of neurological deficits in 6-hydroxydopamine-lesioned rats after transplantation with allogeneic simian virus 40 large tumor antigen gene-induced immortalized dopamine cells

Proceedings of the National Academy of Sciences of the United States of America
E D ClarksonK N Prasad

Abstract

The replacement of dopamine (DA) by DA neuron transplants in the treatment of advanced Parkinson disease (PD) is a rational approach. Because of limitations associated with fetal tissue transplants, a clone (1RB3AN27) of simian virus 40 large tumor antigen (LTa) gene-induced immortalized DA neurons were used in this study. These allogeneic immortalized dopamine neurons, when grafted into striata of normal rats, did not divide, did not form tumors, did not produce LTa, did not extend neurites to host neurons, and were not rejected, for as long as 13 months after transplantation. Grafted cells when recultured in vitro resumed cell proliferation and LTa production, suggesting the presence of a LTa gene-inhibiting factor in the brain. The grafting of undifferentiated and differentiated 1RB3AN27 cells or differentiated murine neuroblastoma (NBP2) cells into striata of 6-hydroxydopamine-lesioned rats (an animal model of PD) caused a time-dependent improvement in neurological deficits (reduction in the methamphetamine-induced turning rate). At 3 months after transplantation, 100% of the animals receiving differentiated 1RB3AN27 cells, 63% of the animals receiving undifferentiated 1RB3AN27 cells, 56% of the animals receiving differenti...Continue Reading

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Citations

Jun 14, 2000·Progress in Neurobiology·G YadidI Gispan
Sep 2, 2003·Seminars in Cell & Developmental Biology·Anselme L Perrier, Lorenz Studer
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Curt R Freed
Aug 22, 2001·In Vitro Cellular & Developmental Biology. Animal·B KumarK N Prasad
Jan 16, 2009·Journal of Molecular Neuroscience : MN·Shankar J ChintaRammohan V Rao
Sep 11, 2010·Free Radical Biology & Medicine·Anamitra GhoshBalaraman Kalyanaraman
Mar 31, 2007·Toxicology and Applied Pharmacology·Derek A DrechselManisha Patel
May 10, 2008·Traffic·Kenneth L MadsenUlrik Gether
Aug 7, 2012·Journal of Cellular and Molecular Medicine·A Alwin Prem AnandV Kokila Vani
Nov 16, 2004·Molecular and Cellular Endocrinology·M J Eaton, H Duplan
Dec 31, 2003·The Journal of Biological Chemistry·Wenbo Zhou, Curt R Freed
May 17, 2019·The Journal of Biological Chemistry·Ryan P McGlincheyJennifer C Lee
May 15, 2003·The Journal of Biological Chemistry·Tatiana SorkinaAlexander Sorkin
Feb 1, 2008·Acta Biochimica Et Biophysica Sinica·Ping ChenLiping Liang
Feb 15, 2019·Prostaglandins & Other Lipid Mediators·Shilpa SontiSamuel J Gatley
Jul 13, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·B S CagleJ A Doorn

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