Oct 5, 2014

Improvement of neuronal bioenergetics by neurosteroids: implications for age-related neurodegenerative disorders

Biochimica Et Biophysica Acta
Amandine GrimmAnne Eckert

Abstract

The brain has high energy requirements to maintain neuronal activity. Consequently impaired mitochondrial function will lead to disease. Normal aging is associated with several alterations in neurosteroid production and secretion. Decreases in neurosteroid levels might contribute to brain aging and loss of important nervous functions, such as memory. Up to now, extensive studies only focused on estradiol as a promising neurosteroid compound that is able to ameliorate cellular bioenergetics, while the effects of other steroids on brain mitochondria are poorly understood or not investigated at all. Thus, we aimed to characterize the bioenergetic modulating profile of a panel of seven structurally diverse neurosteroids (progesterone, estradiol, estrone, testosterone, 3α-androstanediol, DHEA and allopregnanolone), known to be involved in brain function regulation. Of note, most of the steroids tested were able to improve bioenergetic activity in neuronal cells by increasing ATP levels, mitochondrial membrane potential and basal mitochondrial respiration. In parallel, they modulated redox homeostasis by increasing antioxidant activity, probably as a compensatory mechanism to a slight enhancement of ROS which might result from the ri...Continue Reading

  • References41
  • Citations20

Citations

Mentioned in this Paper

Metabolic Process, Cellular
Dihydrorhodamine 123
Real-Time Polymerase Chain Reaction
Androgens and estrogens
Androgen Receptor
Biochemical Pathway
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone
Structure of Calf of Leg
Testosterone Measurement
Cytochrome C Oxidase

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