Improvement of pancreatic cancer model by modified treatment with N-nitroso-bis (2-oxopropyl) amine

Cancer Letters
P PourU Mohr


Comparative studies were conducted in 2 groups of Syrian golden hamsters treated with N-nitroso-bis (2-oxopropyl)amine (BOP) weekly for life (group A) or weekly for 6 weeks (group B), and sacrificed at 2-week intervals. Pancreatic neoplasms developed as early as 8 weeks (group B) and 10 weeks (group A); however, in group B there were fewer, smaller lesions, well-differentiated morphologically. Liver neoplasms occurred only in group A, while gallbladder and kidney tumors were seen in both groups. A lower incidence of pulmonary adenomas was found in group B than in group A, which also had pulmonary carcinomas. The results indicate a further advance in the development of a pancreatic cancer model.


Jan 1, 1989·Journal of Cancer Research and Clinical Oncology·T LawsonD Nagel
Jan 1, 1990·Journal of Cancer Research and Clinical Oncology·J BaxE Scherer
Jul 8, 2011·World Journal of Gastroenterology : WJG·Miroslav ZavoralMarek Minarik
Mar 27, 2012·International Journal of Oncology·Uwe A WittelSurinder K Batra
Jul 1, 1978·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R GingellR Kupper
Jul 1, 1997·Surgery·J A RiveraC Fernández-del Castillo
Feb 18, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Russell G PostierDaniel J Brackett

Related Concepts

Carcinoma, Cribriform
Tumor Promoters
Intraepithelial Neoplasia
Noninfiltrating Intraductal Carcinoma
Malignant Neoplasm of Lung

Related Feeds

Adenoma, Liver Cell

Liver Cell Adenoma or hepatic adenoma is a rare benign tumor. It is associated with birth control use or pregnancy. Discover the latest research on Liver Cell Adenoma here.