Improvement of pancreatic cancer model by modified treatment with N-nitroso-bis (2-oxopropyl) amine

Cancer Letters
P PourU Mohr

Abstract

Comparative studies were conducted in 2 groups of Syrian golden hamsters treated with N-nitroso-bis (2-oxopropyl)amine (BOP) weekly for life (group A) or weekly for 6 weeks (group B), and sacrificed at 2-week intervals. Pancreatic neoplasms developed as early as 8 weeks (group B) and 10 weeks (group A); however, in group B there were fewer, smaller lesions, well-differentiated morphologically. Liver neoplasms occurred only in group A, while gallbladder and kidney tumors were seen in both groups. A lower incidence of pulmonary adenomas was found in group B than in group A, which also had pulmonary carcinomas. The results indicate a further advance in the development of a pancreatic cancer model.

Citations

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Related Concepts

nitrosobis(2-oxopropyl)amine
Carcinoma, Cribriform
Metazoa
Tumor Promoters
Intraepithelial Neoplasia
Noninfiltrating Intraductal Carcinoma
Cricetus
Malignant Neoplasm of Lung
Mesocricetus
Nitrosamines

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