Improvement of pelvic floor-related quality of life and sexual function after vaginal mesh implantation for cystocele: primary endpoint of a prospective multicentre trial

Archives of Gynecology and Obstetrics
J FarthmannChristian Fuenfgeld

Abstract

Pelvic organ prolapse (POP) impairs quality of life (QoL) due to vaginal bulge symptoms and changes in bladder/bowel and sexual function. The effect of alloplastic meshes on QoL is still being discussed. The purpose of this study was to prospectively evaluate the effect of mesh implantation on QoL and sexual function over 1 year. 289 women with cystocele > stage I were included in this prospective multicenter study, with nine hospitals participating (ClinicalTrials.gov NCT01084889). Mesh exposures rates and pelvic floor-related QoL using the validated German version of the p-QoL questionnaire were evaluated as the primary endpoints. Based on a single-sided binominal test with α = 0.05 and a power of 0.80, a sample size of 225 for the mesh exposures was calculated. The mesh used was a 6-arm mesh with titanium coating (TILOOP(®) Total 6, sponsor pfm medical ag, Germany). Preoperative data were compared to 6 and 12 months postoperative data, using Wilcoxon test. The mean age of the patients was 67 years (min 43, max 87). All domains of QoL improved significantly compared after surgery: mean prolapse score dropped from 73.7 to 19.4 after 6 and 16.2 after 12 months (p < 0.001). Sexual function also improved significantly. The rate o...Continue Reading

References

Aug 6, 2004·American Journal of Obstetrics and Gynecology·Rebecca G RogersClifford Qualls
May 6, 2005·International Urogynecology Journal and Pelvic Floor Dysfunction·G Alessandro DigesuStefano Salvatore
Mar 27, 2007·Lancet·J Eric JelovsekMatthew D Barber
Feb 14, 2009·International Urogynecology Journal and Pelvic Floor Dysfunction·F LenzC Sohn
Aug 25, 2009·Obstetrics and Gynecology·Matthew D BarberUNKNOWN Pelvic Floor Disorders Network
Nov 10, 2009·Clinical Trials : Journal of the Society for Clinical Trials·Oana BrosteanuUlrike Zettelmeyer
Jul 31, 2012·American Journal of Obstetrics and Gynecology·Halina M ZyczynskiUNKNOWN Urinary Incontinence Treatment Network
May 2, 2013·The Cochrane Database of Systematic Reviews·Christopher MaherCorina Schmid
Nov 21, 2013·Hernia : the Journal of Hernias and Abdominal Wall Surgery·F Köckerling, C Schug-Pass
Jul 6, 2014·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Aysun KarabulutTülay Alan

❮ Previous
Next ❯

Citations

Jun 8, 2017·Journal of Psychosomatic Obstetrics and Gynaecology·Antonio Simone LaganàSalvatore Giovanni Vitale
Aug 5, 2017·Current Opinion in Obstetrics & Gynecology·Abigail Shatkin-Margolis, Rachel N Pauls
Mar 7, 2018·Female Pelvic Medicine & Reconstructive Surgery·Kaitlin K TouzaMichael H Heit
Feb 23, 2017·Archives of Gynecology and Obstetrics·Michele Carlo SchiaviPierluigi Benedetti Panici
Jun 25, 2020·International Urogynecology Journal·Serdar AydınÇağrı Arıoğlu
Jan 4, 2021·BMC Women's Health·Tadesse BelaynehTadesse Awoke Ayele
May 25, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Zaki SleimanGhida Radwan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.