PMID: 6414186Jan 1, 1983Paper

Improvement of plasma quality as raw material for factor VIII:C concentrates. Storage of whole blood and plasma and interindividual plasma levels of fibrinopeptide A

Vox Sanguinis
G CarlebjörkO Akerblom

Abstract

Blood collected into different anticoagulants was stored in small tubes at +4 degrees C for up to 26 h. Seven blood coagulation analyses were performed under standardized conditions. High yield and stability of factor VIII:C were found for ACD and CPD-adenine. No changes could be found in the other six parameters tested. Whole blood in blood bags could be stored for 2-4 h at +4 degrees C with maximal yield of F VIII:C, with blood stored overnight the recovery was 65%. In plasma F VIII:C was stable for at least 2 h at room temperature. F VIIIR:Ag and F VIIIR:RCoF were stable in both whole blood and plasma. No activation by plasmin as measured by B beta 15-42 could be demonstrated. The initial FPA levels, reflecting thrombin activation, in the donated blood differed individually and in some blood bags very high concentrations were found. The levels of FPA were not correlated to the time for collection of a bag of blood.

References

Jan 1, 1975·Vox Sanguinis·A KreugerC F Högman
Nov 1, 1976·Transfusion·S J SlichterL A Harker
Jul 1, 1975·Transfusion·C K KasperD I Feinstein
Jan 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·C B Laurell
Jul 1, 1974·The Journal of Clinical Investigation·H L NosselG D Qureshi
May 1, 1980·Thrombosis Research·K W Denson, C W Redman
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Citations

Jun 1, 1992·Transfusion Medicine·J WallvikM Blombäck
Nov 4, 1994·Transfusion Science·J K Smith
Apr 1, 1989·Scandinavian Journal of Clinical and Laboratory Investigation·I Vaara, M Jonsson
Jan 1, 1984·Vox Sanguinis·C V ProwseJ Gabra
Jan 1, 1986·Vox Sanguinis·O H SkjønsbergH C Godal
Dec 20, 2005·Vox Sanguinis·A-M Swärd-NilssonS Lethagen
Jul 19, 2012·Transfusion·Martin MacPheeGary Moroff

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