PMID: 9433375Jan 20, 1998Paper

Improvement of prognosis in refractory and relapsed acute promyelocytic leukemia over recent years: the role of all-trans retinoic acid therapy

Annals of Hematology
X ThomasE Archimbaud

Abstract

With the aim of determining the ability of all-trans retinoic acid (ATRA) to improve prognosis in refractory and relapsed acute promyelocytic leukemia (APL), the data of 45 patients resistant to previous conventional chemotherapy or in first relapse were retrospectively reviewed. Thirty-seven patients presented with typical M3, five with variant form (M3v), and three with intermediate form. Seven patients died before any chemotherapy could be given. Thirty-five patients received one course of chemotherapy combining anthracyclines and cytarabine without (n = 22) or with ATRA (n = 13), according to different protocols. One elderly patient received only ATRA, and two patients received only low-dose cytarabine. Nine patients died within 4 weeks of relapse. A complete remission (CR) was achieved in 29 of the 38 patients retreated after first relapse or primary failure (76.3%, 95% CI: 60-89%). Among relapsed patients, four of five patients who had initially received ATRA therapy achieved a second CR when retreated by ATRA. The median second disease-free survival (DFS) was 23.3 months. Overall median survival was 7.8 months, with a 5-year survival rate of 29% (95% CI: 14-44%). Parameters found to be associated with decreased second CR...Continue Reading

Citations

Feb 1, 1996·Cancer Genetics and Cytogenetics·N HdaA Benslimane
Jun 27, 2000·Australian and New Zealand Journal of Medicine·A Spencer, F Firkin
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dan Douer, Martin S Tallman
Sep 6, 2001·Bone Marrow Transplantation·C NabhanM S Tallman
May 13, 2011·Journal of Animal Physiology and Animal Nutrition·D JamrozT Stefaniak

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