Improvement of PTSD-like behavior by the forgetting effect of hippocampal neurogenesis enhancer memantine in a social defeat stress paradigm

Molecular Brain
Rie IshikawaSatoshi Kida

Abstract

Post-traumatic stress disorder (PTSD) is a psychiatric disorder associated with memories of traumatic experiences. Recent studies have shown that the forgetting of contextual fear memory is promoted via increased adult hippocampal neurogenesis induced by neurogenesis enhancers, such as memantine (MEM) and exercise, raising the possibility that neurogenesis enhancers improve PTSD by facilitating the forgetting of traumatic memory. On the other hand, repeated exposure to social defeat (SD) stress by aggressor mice induces social avoidance behavior to the aggressor and chronic anxiety-like behavior. In this study, we assumed this SD stress paradigm as a PTSD-like model and examined the effects of treatment with neurogenesis enhancer MEM on SD stress-induced PTSD-like behavior. Male C57BL/6 mice received SD stress for 10 consecutive days and were assessed for social avoidance memory to the aggressor (memory of aggressor mice) and anxiety-like behavior using social interaction and elevated zero maze tasks. Consistent with previous studies, SD mice formed social avoidance memory and exhibited increased anxiety-like behavior. Importantly, subsequent MEM treatment (once a week for 4 weeks) significantly reduced social avoidance behavio...Continue Reading

References

Sep 16, 2005·Journal of Nutritional Science and Vitaminology·Shusaku UchidaSatoshi Kida
May 30, 2008·Learning & Memory·Daniela SchillerElizabeth A Phelps
Nov 26, 2009·Behavioural Brain Research·Devin Mueller, Shawn P Cahill
Mar 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kohei TanakaShuh Narumiya
Jun 15, 2012·Journal of Psychiatric Research·Brett T LitzStefan G Hofmann
May 9, 2014·Science·Katherine G AkersPaul W Frankland
May 9, 2015·Nature Communications·Rosemary C BagotEric J Nestler
May 5, 2017·Nature Reviews. Neuroscience·Christoph Anacker, René Hen

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Citations

Mar 13, 2020·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Satoshi Kida
Mar 27, 2020·Frontiers in Neuroscience·Cuicui LiChenglin Zhou
Nov 15, 2020·Scientific Reports·Midori NagaiTomoyuki Furuyashiki
Mar 9, 2021·European Journal of Psychotraumatology·Hiroaki HoriYoshiharu Kim
Jun 28, 2021·Neurobiology of Learning and Memory·Shogo SomaSatoshi Shimegi
Jul 4, 2021·Behavioural Brain Research·Inara Fernanda Misiuta Raupp-BarcaroRoberto Andreatini

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