Abstract
Post-traumatic stress disorder (PTSD) is a psychiatric disorder associated with memories of traumatic experiences. Recent studies have shown that the forgetting of contextual fear memory is promoted via increased adult hippocampal neurogenesis induced by neurogenesis enhancers, such as memantine (MEM) and exercise, raising the possibility that neurogenesis enhancers improve PTSD by facilitating the forgetting of traumatic memory. On the other hand, repeated exposure to social defeat (SD) stress by aggressor mice induces social avoidance behavior to the aggressor and chronic anxiety-like behavior. In this study, we assumed this SD stress paradigm as a PTSD-like model and examined the effects of treatment with neurogenesis enhancer MEM on SD stress-induced PTSD-like behavior. Male C57BL/6 mice received SD stress for 10 consecutive days and were assessed for social avoidance memory to the aggressor (memory of aggressor mice) and anxiety-like behavior using social interaction and elevated zero maze tasks. Consistent with previous studies, SD mice formed social avoidance memory and exhibited increased anxiety-like behavior. Importantly, subsequent MEM treatment (once a week for 4 weeks) significantly reduced social avoidance behavio...Continue Reading
References
Sep 16, 2005·Journal of Nutritional Science and Vitaminology·Shusaku UchidaSatoshi Kida
Feb 14, 2006·Science·Olivier BertonEric J Nestler
Oct 25, 2007·Cell·Vaishnav KrishnanEric J Nestler
May 30, 2008·Learning & Memory·Daniela SchillerElizabeth A Phelps
Mar 5, 2009·Molecular Brain·Shunsuke HasegawaSatoshi Kida
Nov 26, 2009·Behavioural Brain Research·Devin Mueller, Shawn P Cahill
Dec 8, 2009·Journal of Anxiety Disorders·Dorothée BentzFrank H Wilhelm
Mar 24, 2010·Molecular Psychiatry·R J SchloesserM Herkenham
Mar 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kohei TanakaShuh Narumiya
Jun 15, 2012·Journal of Psychiatric Research·Brett T LitzStefan G Hofmann
Mar 7, 2014·Hippocampus·Rie IshikawaSatoshi Kida
May 9, 2014·Science·Katherine G AkersPaul W Frankland
May 9, 2015·Nature Communications·Rosemary C BagotEric J Nestler
Sep 27, 2016·ELife·Rie IshikawaSatoshi Kida
May 5, 2017·Nature Reviews. Neuroscience·Christoph Anacker, René Hen
Jul 24, 2018·Neuron·Xiang NieTomoyuki Furuyashiki
Oct 31, 2018·Psychopharmacology·Satoshi Kida
Citations
Mar 13, 2020·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Satoshi Kida
Sep 12, 2020·Molecular Neurobiology·Martina Stazi, Oliver Wirths
Mar 27, 2020·Frontiers in Neuroscience·Cuicui LiChenglin Zhou
Nov 15, 2020·Scientific Reports·Midori NagaiTomoyuki Furuyashiki
Jan 25, 2021·Biological Psychiatry·Ja Wook Koo, Eric S Wohleb
Mar 9, 2021·European Journal of Psychotraumatology·Hiroaki HoriYoshiharu Kim
Mar 8, 2021·Brain, Behavior, and Immunity·Shohei TakahashiSatoshi Kida
May 16, 2021·Brain and Behavior·Katsumasa SogoYoshie Okawa
Jun 28, 2021·Neurobiology of Learning and Memory·Shogo SomaSatoshi Shimegi
Jul 18, 2021·Neuropharmacology·Xiaohang CheJingyu Yang
Jul 4, 2021·Behavioural Brain Research·Inara Fernanda Misiuta Raupp-BarcaroRoberto Andreatini
Aug 28, 2021·Cancers·Pi-Shan SungChou-Ching K Lin
Sep 28, 2021·Molecular Brain·Yi-Hung ChenDah-Yuu Lu