PMID: 8944331Jan 1, 1996Paper

Improvement of quality control for steroid receptor measurements: analysis of distributions in more than 40000 primary breast cancers. French Study Group on Tissue and Molecular Biopathology

Breast Cancer Research and Treatment
S RomainH Magdelenat

Abstract

All French laboratories that routinely assay estradiol (ER) and progesterone (PR) receptors participate in the European EORTC quality control program based on twice-yearly analysis of 5 cytosolic preparations. This system has considerably reduced inter-laboratory variations, but does not cover all aspects of these assays. Analysis of receptor value distributions is also crucial to ensure that receptor measurements remain stable with time, independently of the laboratory and assay method. This study involved 83907 receptor assays carried out in the last 17 years by 17 laboratories belonging to the French Study Group on Tissue and Molecular Biopathology. The assays were based on radioligand binding (RLA) or immunoenzymology (EIA). For each laboratory, the medians and positivity rates were analysed according to two totally objective criteria, the patient's age and the year of assay, and according to histological grade and histological type of the tumor in order to verify the correlations classically described. Age-related distributions varied little between laboratories, compared with data published by 7 European EORTC laboratories [1]. The results remained relatively stable with time in the RLA method for ER and PR, and in the EI...Continue Reading

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Citations

Jul 6, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Chafika MazouniPierre-Marie Martin
Sep 15, 2001·Applied Immunohistochemistry & Molecular Morphology : AIMM·M Ferrero-PoüsF Spyratos
Mar 31, 1999·British Journal of Cancer·S M EngerL Bernstein
Jun 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P BroëtF Spyratos

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