Improvement of reduced serum cartilage oligomeric matrix protein levels in systemic juvenile idiopathic arthritis patients treated with the anti-interleukin-6 receptor monoclonal antibody tocilizumab

Modern Rheumatology
Shoko NakajimaShumpei Yokota

Abstract

In this study, we determined serum cartilage oligomeric matrix protein (COMP) levels in systemic juvenile idiopathic arthritis (sJIA) patients during both the active and the remission phases to investigate how the growth cartilage turnover changed under tocilizumab treatment. Specimens were collected from 201 healthy children under 16 years of age with no growth impairment, and paired sera were collected from 11 sJIA patients treated with tocilizumab. Disease activity was assessed from white blood cell count, erythrocyte sedimentation rate, C-reactive protein, and ferritin, and the COMP concentration was determined by sandwich enzyme-linked immunosorbent assay. Serum COMP concentrations were found independent of age, and the mean value in healthy children was 17.74+/-5.6 U/L. The mean serum COMP in sJIA patients during the active phase was 10.75+/-3.9 U/L, lower than that of healthy children. The mean serum COMP in the remission phase (14.89+/-3.9 U/L) was significantly higher than that in the active period (P<0.05). These results suggested that in sJIA patients, a reduced serum COMP concentration is a useful marker of active disease and growth impairment, and that the growth cartilage turnover suppressed during the active phas...Continue Reading

References

Jan 16, 1999·Baillière's Clinical Rheumatology·R E Petty
Oct 9, 2004·The Journal of Clinical Endocrinology and Metabolism·R BjarnasonUNKNOWN Swedish Study Group for Growth Hormone Treatment
Sep 1, 2005·Clinical Reviews in Allergy & Immunology·Shumpei YokotaMasaaki Mori
Oct 10, 2006·Modern Rheumatology·Shumpei YokotaMasaaki Mori
Nov 1, 2006·Nature Clinical Practice. Rheumatology·Norihiro Nishimoto, Tadamitsu Kishimoto

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Citations

Jul 14, 2012·International Journal of Inflammation·Clio P MavraganiMichael Koutsilieris
Dec 12, 2012·Therapeutic Advances in Musculoskeletal Disease·Shumpei YokotaTadamitsu Kishimoto
Mar 22, 2014·International Journal of Endocrinology·Cosimo GianniniFrancesco Chiarelli

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