Improvement of refractory migraine headache by propofol: case series.

International Journal of Emergency Medicine
Hassan SoleimanpourMaryam Soleimanpour

Abstract

Several studies have been conducted on managing migraine headaches and developing effective medications for decreasing migraine-associated pain. Intravenous propofol was prescribed (10 mg every 5 min) for eight patients with intractable migraine headaches visiting the Emergency Department. The average pain score experienced by patients was recorded using the Visual Analogue Scale at the beginning of the treatment procedure and following the injection for 30 min (5-min intervals). The patients' reported pain scores decreased significantly (P = 0.01) from 8.87 ± 0.83 (CI: 8.17, 9.57) to 1.12 ± 0.83 (CI: 0.43, 1.82) before and 30 min following the injection. It seems that in the treatment of intractable migraine headaches, GABAergic receptors, compared to the normal conditions, have a lower activity status. Because of the high tendency of propofol to GABAergic receptors, it probably changes this physiological condition by activating the receptors, which results in a significant pain reduction.

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Citations

Jun 10, 2014·Anesthesiology and Pain Medicine·Sajjad RazaviAlireza Mirkheshti
Feb 15, 2013·Headache·Elliott Schulman
Nov 15, 2013·Emergency Medicine Australasia : EMA·David I WardDean Morgan
May 30, 2015·Journal of Translational Medicine·Krystyna M WozniakBarbara S Slusher
Feb 24, 2015·Current Neurology and Neuroscience Reports·Michael J Marmura, Stephanie Wrobel Goldberg
Mar 21, 2015·Anesthesiology and Pain Medicine·Hassan SoleimanpourSeyed Moayed Alavian
Aug 12, 2016·Annals of Emergency Medicine·Benjamin W Friedman
Oct 12, 2019·Headache·Abigail L ChuaRandolph W Evans
Feb 23, 2019·Turkish Journal of Emergency Medicine·David H Cisewski, Sergey M Motov
Apr 4, 2018·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·David GiampetroRobert Knipe
Apr 30, 2019·Advanced Emergency Nursing Journal·Jennifer Jesani, Darlie Simerson
Feb 6, 2018·The Journal of Emergency Medicine·Brit J Long, Alex Koyfman

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Methods Mentioned

BETA
sedation

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