PMID: 8590258Jan 1, 1995Paper

Improvement of retinal functions after ischemia with L-arginine and its derivatives

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
S X LiuR S Varma

Abstract

Retinal ischemia was created by occlusion of rat central retinal artery for 30 minutes. The loss of retinal function was indicated by the loss of b-wave of electroretinogram. The recovery of retinal function after reperfusion of central retinal artery was observed with the gradual recovery of b-wave amplitude to approximately 20% of original b-wave amplitude. When L-arginine (RVC-579) was administered at the time of retina ischemia, the b-wave amplitudes recovered up to 64% of original height and were significantly higher than corresponding controls at 120, 180, and 240 min after ischemia. When the derivative of L-arginine, N alpha-benzoyl-L-arginine ethyl ester (RVC-578), was administered, the b-wave recovery was significantly higher than corresponding controls at 90, 120, 180, and 240 min after ischemia; the recovery reached 51% of the original b-wave value. These results indicate that the L-arginine and its lipophilic derivatives could be used for the treatment of ischemic retinopathy. Since L-arginine is a natural amino acid, it is not expected to produce major side effects, if any, and could pave the way for the development of a safer drug to be used in the clinics. Compounds which increase the formation of NO in vivo, dil...Continue Reading

References

Jan 1, 1993·Journal of Ocular Pharmacology·G C Chiou, B H Li
Jan 1, 1995·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·G C ChiouR S Varma

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Citations

Jul 28, 1999·European Journal of Pharmacology·M C Koss
Oct 6, 2001·Progress in Retinal and Eye Research·L Schmetterer, K Polak
Apr 1, 1997·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·S D VarmaS M Morris
Dec 8, 2000·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·C J ChangD W Lu
Apr 1, 1997·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·S X LiuG C Chiou
Feb 24, 2001·International Ophthalmology Clinics·R H Farkas, C L Grosskreutz
Aug 24, 2019·Translational Vision Science & Technology·Nanna VestergaardHenrik Vorum

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Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
S X LiuG C Chiou
Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
G C ChiouR S Varma
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