Improvement of Risk Prediction After Transcatheter Aortic Valve Replacement by Combining Frailty With Conventional Risk Scores

JACC. Cardiovascular Interventions
Andreas W SchoenenbergerStefan Stortecky

Abstract

This study sought to evaluate whether frailty improves mortality prediction in combination with the conventional scores. European System for Cardiac Operative Risk Evaluation (EuroSCORE) or Society of Thoracic Surgeons (STS) score have not been evaluated in combined models with frailty for mortality prediction after transcatheter aortic valve replacement (TAVR). This prospective cohort comprised 330 consecutive TAVR patients ≥70 years of age. Conventional scores and a frailty index (based on assessment of cognition, mobility, nutrition, and activities of daily living) were evaluated to predict 1-year all-cause mortality using Cox proportional hazards regression (providing hazard ratios [HRs] with confidence intervals [CIs]) and measures of test performance (providing likelihood ratio [LR] chi-square test statistic and C-statistic [CS]). All risk scores were predictive of the outcome (EuroSCORE, HR: 1.90 [95% CI: 1.45 to 2.48], LR chi-square test statistic 19.29, C-statistic 0.67; STS score, HR: 1.51 [95% CI: 1.21 to 1.88], LR chi-square test statistic 11.05, C-statistic 0.64; frailty index, HR: 3.29 [95% CI: 1.98 to 5.47], LR chi-square test statistic 22.28, C-statistic 0.66). A combination of the frailty index with either Euro...Continue Reading

Citations

Dec 21, 2018·Circulation·Yee-Ping Sun, Patrick T O'Gara
Jan 17, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Anton CamajGeorge D Dangas
Jun 6, 2020·Acta Cardiologica·Sofie Van de Velde-Van De GinsteAnne-Marie De Cock
Jun 20, 2020·Expert Review of Cardiovascular Therapy·Antonio Giulio BrunoFrancesco Saia
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Jul 21, 2020·Current Gerontology and Geriatrics Research·Louis KoiziaMichael B Fertleman
Aug 14, 2020·BMC Geriatrics·Andreas W SchoenenbergerRichard Kobza
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Jan 25, 2020·JACC. Cardiovascular Interventions·Christopher AllenBernard Prendergast
Jan 25, 2020·JACC. Cardiovascular Interventions·Soroosh KianiUNKNOWN STS/ACC TVT Registry
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Jan 8, 2022·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Ankit Upadhyay, Hani Jneid

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