Improvement of skin quality using a new collagen scaffold in acute burns and reconstructive surgery: an in vivo evaluation of split skin graft transplantation in a rat model

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Afshin Rahmanian-SchwarzBernhard Hirt

Abstract

Split-thickness skin grafting is often associated with poor skin quality. In this context, a new collagen cell carrier (CCC), as an underlayment in split skin graft (SSG) transplantation for covering tissue defects in rats, has been evaluated as an improving agent. Twenty-eight full-thickness wounds were covered with SSGs, applying the CCC as an underlayment in 14 rats and using SSG transplantation alone in control group. Postgraft skin areas were assessed using an instrument that measures mechanical properties of skin. Three parameters were considered for skin elasticity analysis: total skin deviation (R0), gross elasticity (R2) and viscoelasticity (R8). Measurements were performed every 10 days for 80 days after grafting. Biopsies were taken subsequently for histologic evaluation. The results demonstrated significantly superior elasticity values in CCC-supplemented SSGs in terms of gross elasticity and viscoelasticity (R2/R8) starting from day 60 after grafting to the end of the measuring period. There was no histologic evidence of inflammation, adverse host tissue reaction, or scar tissue formation. Split skin grafting is associated with poor dermal quality, but CCC may offer unique opportunities in complex wound management ...Continue Reading

References

Aug 1, 1992·Journal of the American Academy of Dermatology·T M JohnsonB R Nelson
May 1, 1990·The British Journal of Dermatology·P ElsnerH I Maibach
Jan 1, 1973·International Review of Connective Tissue Research·M ChvapilW Van Winkle
Jan 1, 1980·Journal of Biomedical Materials Research·I V Yannas, J F Burke
Jan 1, 1995·Journal of Biomaterials Science. Polymer Edition·N BarbaniG Pizzirani
Sep 1, 1996·Journal of the American Academy of Dermatology·D N EnomotoJ D Bos
Mar 1, 1997·Burns : Journal of the International Society for Burn Injuries·S S FongJ C Cheng
Mar 1, 1997·Burns : Journal of the International Society for Burn Injuries·W W KingA K Li
Jul 14, 2001·Burns : Journal of the International Society for Burn Injuries·P Shakespeare
Dec 18, 2001·Plastic and Reconstructive Surgery·P P van ZuijlenE Middelkoop
Mar 7, 2003·Aesthetic Plastic Surgery·Bishara S AtiyehRuwayda Dham
Jul 6, 2007·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Farina Hashmi, James Malone-Lee
Oct 30, 2009·Burns : Journal of the International Society for Burn Injuries·Dai Q A NguyenPatricia Price
Apr 5, 2011·Plastic and Reconstructive Surgery·Afshin Rahmanian-SchwarzHans-Eberhard Schaller
Sep 10, 2011·Tissue Engineering. Part C, Methods·Timo SchmidtLothar Just
Mar 24, 2012·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Afshin Rahmanian-SchwarzPatrick Jaminet

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Citations

Dec 3, 2014·Acta Biomaterialia·Henk R HoogenkampWilleke F Daamen
Jan 17, 2015·Biomaterials·Elizabeth R LordenHoward Levinson
May 14, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Manuel HeldWiebke Petersen
Jun 15, 2016·Burns : Journal of the International Society for Burn Injuries·Wiebke PetersenManuel Held
Feb 17, 2019·Nature Communications·Kevin BircherEdoardo Mazza

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