PMID: 15374128Mar 1, 1997Paper

Improvement of sleep quality by controlled-release melatonin in benzodiazepine-treated elderly insomniacs

Archives of Gerontology and Geriatrics
D GarfinkelN Zisapel

Abstract

Benzodiazepines are widely used in the elderly population for the initiation of sleep. However, very frequently, complaints about poor sleep maintenance persist despite benzodiazepine treatment. Melatonin, a hormone produced by the pineal gland at night, is involved in the regulation of the sleep/wake cycle. Melatonin production decreases with age and can also be inhibited by benzodiazepines. We have recently reported on the association between insomnia and impaired melatonin output in the elderly. In the present study we have investigated the efficacy of melatonin replacement therapy in improving sleep in 21 elderly subjects who have been taking benzodiazepines and had low melatonin output. In a randomized, double-blind, crossover designed study the subjects were treated for three weeks with 2 mg per night of controlled-release melatonin and for 3 weeks with placebo, 2 h before desired bedtime with a 1-week washout period between treatment periods. Subjects' sleep was assessed by wrist actigraphy. Melatonin treatment significantly increased sleep efficiency and total sleep time and decreased wake after sleep onset, sleep latency, number of awakenings and fragmental index, as compared to placebo. The results of our study indica...Continue Reading

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Citations

Aug 10, 2006·Journal of Autism and Developmental Disorders·F GiannottiP Bernabei
Oct 10, 2012·Drugs & Aging·Katherine A Lyseng-Williamson
Sep 16, 2000·Archives of Gerontology and Geriatrics·J Cohen-MansfieldS Lipson
Apr 17, 2002·Maturitas·Uwe D Rohr, Jens Herold
Jan 21, 2006·Journal of General Internal Medicine·Nina BuscemiSunita Vohra
Nov 21, 2007·CNS Drugs·Seithikurippu R Pandi-PerumalDaniel P Cardinali
Jun 23, 2010·Clinical Medicine Insights. Oncology·Z NahlehS Sweany
Oct 27, 2012·Experimental Neurology·A Jennifer Morton
Sep 1, 2012·Experimental Neurology·Aleksandar Videnovic, Diego Golombek
Nov 19, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Taina MattilaTamar Wohlfarth
Nov 30, 2013·British Journal of Clinical Pharmacology·Ritva LähteenmäkiSirkka-Liisa Kivelä
Oct 24, 2002·Primary Care·Michele M Larzelere, Pamela Wiseman
Sep 24, 2008·Expert Opinion on Investigational Drugs·Alan Wade, Susan Downie
Nov 22, 2005·Chronobiology International·Mark R SmithCharmane I Eastman
Jan 18, 2003·Sleep Medicine Reviews·Avi Sadeh, Christine Acebo
Jun 1, 2011·Therapeutic Advances in Psychopharmacology·Colm Devine
Jan 18, 2003·Human Psychopharmacology·Neil Stanley
Apr 5, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wen-Wen LiuChun-Feng Liu
Dec 21, 2016·Neuroscience Bulletin·Siyue LiChun-Feng Liu
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