PMID: 22568319May 10, 2012Paper

Improvement of spinal cord semi-transected and lump defect model by quantitate semi-transected blade in rats

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Wei HuBo Yang

Abstract

To investigate the effect of quantitative semi-transected blade on the improvement of spinal cord semi-transected and lump defect model. Forty-eight male Sprague Dawley rats (weighing 220-250 g) were divided into the experimental group (n = 24) and control group (n = 24). The spinal cord semi-transected and lump defect model was made by self-made quantitative semi-transected blade in the experimental group, and by ophthalmic scalpel in the control group. Then, the complications were observed; the electrophysiological results were detected before modeling and at 21 days after modeling; the histological changes at margin of lump defect were observed at 6 hours, 5 days, and 28 days; Basso, Beattie, and Bresnahan (BBB) scores were detected at 1, 3, 5, 7, 14, 21, 28, 35, 42, 56, and 84 days after modeling. There was significant difference in the mortality between the experimental group (0) and the control group (26.67%) (P = 0.028). Electrophysiological examination: there was no significant difference in latency and amplitude of motor evoked potentials (MEP) and sensory evoked potentials (SEP) between 2 groups at preoperation (P > 0.05); at 21 days after operation, latencies of MEP and SEP increased and the amplitude decreased in th...Continue Reading

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