Improvement of telbivudine on renal function and massive proteinuria: A case report

Journal of Viral Hepatitis
J LiuY Zhao

Abstract

The quality of life and extended survival of patients with chronic hepatitis B (CHB), especially those with decompensated liver cirrhosis, has been improved markedly with nucleos(t)ide analogs treatment. In such conditions, the influence of hepatitis B virus (HBV) infection and antiviral agents on renal function becomes a consideration with long-term use and ageing. Membranous glomerulonephritis has been confirmed as the most common histological renal lesion. In this study, we reported a CHB patient with decompensated cirrhosis showing a significant improvement in massive proteinuria along with elevation of estimated glomerular filtration rate (eGFR) after 1 year treatment with telbivudine. However, a well-designed study should be performed to confirm the causal association, and the molecular mechanism needs further investigation.

References

Sep 27, 2013·Gastroenterology·Edward J GaneAldo Trylesinski
Jan 1, 2014·Journal of Gastroenterology and Hepatology·James FungMan-Fung Yuen
Jan 3, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jian SunJinlin Hou
Aug 29, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fu-Sheng WangHong-Yang Wang

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Citations

Dec 19, 2017·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Andrew Lucas, Kin Chung Fong

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