Nov 7, 2019

Improvement of the Immunochromatographic NG-Test Carba 5 Assay for the Detection of IMP Variants Previously Undetected

Antimicrobial Agents and Chemotherapy
Hervé VollandT Naas

Abstract

Here, we evaluated the immunochromatographic assay NG-Test Carba 5v2 (NG-Biotech), with improved IMP variant detection on 31 IMP producers, representing the different branches of the IMP phylogeny, including 32 OXA-48, 19 KPC, 12 VIM, 14 NDM, and 13 multiple carbapenemase producers (CPs), 13 CPs that were not targeted, and 13 carbapenemase-negative isolates. All tested IMP variants were accurately detected without impairing detection of the other carbapenemases. Thus, NG-Test Carba 5v2 is now well adapted to countries with high IMP prevalence and to the epidemiology of CP-Pseudomonas aeruginosa, where IMPs are most frequently detected.

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Mentioned in this Paper

Carboplatin/Ifosfamide
Methylnitronitrosoguanidine
Carbapenemase
Immunochromatographic Assay
Pseudomonas aeruginosa
Isolate - Microorganism
Imipenem
Drug Implant
Epidemiology
IMP Dehydrogenase

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