Improvement of transdermal delivery of sumatriptan succinate using a novel self-dissolving microneedle array fabricated from sodium hyaluronate in rats

Biological & Pharmaceutical Bulletin
Dan WuAkira Yamamoto

Abstract

The purpose of the present study was to develop an alternative transdermal formulation containing sumatriptan succinate (SS) for the treatment of migraine. Novel self-dissolving SS-loaded microneedle arrays (MNs) were fabricated from sodium hyaluronate and their efficacy for transdermal delivery of SS was characterized. The resulting MNs maintained their skin piercing abilities for at least 30 min after being placed at a high relative humidity of 75%. Rapid release of SS from the MNs was also observed in vitro. Optical coherence tomography images demonstrated that MNs were able to successfully pierce into rat skin without any bending or cracking, and needles were completely dissolved within 1 h. MNs significantly increased transepidermal water loss; however, skin barrier function gradually recovered to control levels within 24 h, in contrast to the skin damage observed after tape stripping treatment. These findings indicated that the micropores created by MNs quickly resealed, and that the skin damage was reversible. Furthermore, a dose-dependent plasma concentration of SS was obtained after transdermal delivery using SS-loaded MNs in rats. Absorption of SS delivered by MNs was similar to that observed after subcutaneous inject...Continue Reading

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Citations

Jan 23, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anthony P RaphaelMark A F Kendall
Mar 21, 2019·Drug Delivery and Translational Research·Wei WangFan Chen
Jan 11, 2017·Biomedical Microdevices·Sung-Hyun BaekYeu-Chun Kim
Oct 21, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cetin TasMark R Prausnitz

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