Improvement on the performance of bone regeneration of calcium sulfate hemihydrate by adding mineralized collagen

Tissue Engineering. Part a
Huan-Ye LiuFuzhai Cui

Abstract

Comparative investigations of bone regeneration performance for calcium sulfate hemihydrate (CaSO(4).(1/2)H(2)O; CSH) only and CSH with mineralized collagen are reported in this article. The mineralized collagen is the nanohydroxyapatite/collagen (nHAC). The investigations included biocompatibility in vitro and performance of bone repair in vivo. Quantitative and qualitative biocompatibility assays with bone stromal stem cells were performed. A critical box-shaped defect model in the mandible of the rabbit was used to evaluate the bone-remodeling ability of CSH and nHAC/CSH. Results in vitro indicated that the nHAC/CSH significantly improved bioactivity compared with that of CSH, especially in promoting cell adhesion. Further, a higher bone remodeling activity was observed around nHAC/CSH composite than the CSH, especially at the early stage of remodeling. This result means that nHAC/CSH could cause an earlier accelerator and better osseointegration for bone repair than CSH only.

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Citations

Feb 1, 2013·Journal of Tissue Engineering and Regenerative Medicine·Xue ZhangFu-Zhai Cui
Jun 27, 2015·BioMed Research International·Shanchuan ZhangHongchen Liu
Jan 13, 2015·Journal of Materials Science. Materials in Medicine·Xue HanWei Zhou
May 21, 2019·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Patricia L CarlislePamela R Brown Baer

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Methods Mentioned

BETA
scanning
X-ray
flow cytometry
PCR
scanning electron microscopy

Software Mentioned

SPSS
DeclareMathSizes
ModFit

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