Improvements in breast cancer survival between 1995 and 2012 in Denmark: The importance of earlier diagnosis and adjuvant treatment

Acta Oncologica
Maj-Britt JensenDanish Breast Cancer Cooperative Group

Abstract

Background Breast cancer mortality has declined from 1995 through 2012 which may be attributed to earlier diagnosis, changes in lifestyle risk factors, and improved treatments. To a large extent the relative contribution of these modalities are unknown. Mammography screening was introduced late in Denmark; in 1995 around 20% of the Danish female population aged 50-69 was covered by population-based screening, and this was in 2008 extended to the entire population. Breast conserving surgery gradually replaced mastectomy, and sentinel node biopsy was introduced. In the same period adjuvant treatment was extended considerable. Methods A population-based study of 68 842 breast cancer patients registered in the clinical database of the Danish Breast Cancer Cooperative Group in 1995-2012. Comprehensive data on prognostic factors, comorbidity and treatment together with complete follow-up for survival were used to evaluate improvements in mortality and standardized mortality rate in successive time periods. Results The results from this study demonstrated a significant improvement in prognosis in successive time periods covering 1995-2012. Apart from patients with a high Charlson Comorbidity Index (CCI) improvements were seen in all s...Continue Reading

References

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Citations

Dec 26, 2017·Acta Oncologica·Marianne D LautrupPeer Christiansen
Nov 18, 2017·Acta Oncologica·Cai GrauJens Overgaard
Jan 14, 2019·Health Expectations : an International Journal of Public Participation in Health Care and Health Policy·Ingrid Annette ZøylnerPia Kirkegaard
Dec 13, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·F RosenbaekJeanette Dupont Jensen
Nov 24, 2017·Acta Oncologica·Bent KristensenUNKNOWN Danish Breast Cancer Cooperative Group
Jul 25, 2020·JMIR MHealth and UHealth·Antonio Augusto Claudio PereiraTiago Franklin Rodrigues Lucena
Aug 1, 2019·Breast Cancer Research and Treatment·Mathilde GottschauSusanne K Kjær
Apr 23, 2020·Scientific Reports·Ina Mathilde KjærJonna Skov Madsen
Jul 1, 2019·Breast Disease·Marco MelePeer M Christiansen
Sep 7, 2018·Breast Cancer Research and Treatment·Ian S Fentiman
Oct 8, 2020·Scientific Reports·Ina Mathilde KjærJonna Skov Madsen
Jan 31, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Marie Louise Holm MiloBirgitte Vrou Offersen
Aug 28, 2021·Cancer Epidemiology·Christiane E S RudolphAlexander Katalinic

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