Improvements in insulin sensitivity are blunted by subclinical hypothyroidism

Medicine and Science in Sports and Exercise
Francesca AmatiBret H Goodpaster

Abstract

Exercise- and weight loss-induced improvements in insulin resistance (IR) are variable; some individuals experience robust enhancements in insulin sensitivity, whereas others do not. Thyroid hormone status is related to IR, but it is not clear whether subclinical hypothyroidism may help to explain the variability in improvements in IR with diet and exercise. The purpose of this study was to examine whether thyroid hormone status is related to the improvement in insulin sensitivity and physical fitness after weight loss and exercise training. By retrospective nested case-control analysis, eight subclinical hypothyroid (sHT) subjects and eight matched euthyroid controls underwent a euglycemic hyperinsulinemic clamp and peak oxygen uptake test, before and after a 16-wk program of moderate aerobic exercise combined with diet-induced weight loss. All subjects were middle-aged (57.3 +/- 3.3 yr), were overweight to obese (body mass index = 33.1 +/- 0.8 kg m(-2)), and had impaired glucose tolerance. The improvement in insulin sensitivity was significantly lower (P < 0.05) in the sHT group than in the euthyroid group. Both groups performed similar amounts of regular exercise and lost a significant amount of body weight during the interv...Continue Reading

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Citations

Feb 12, 2014·Thyroid : Official Journal of the American Thyroid Association·Francisco Zacaron WerneckMário Vaisman
Jun 23, 2009·Molecular and Cellular Endocrinology·Thomas Reinehr
Mar 20, 2010·Journal of Biomedicine & Biotechnology·Melpomeni PeppaSotirios A Raptis
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Sep 18, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ozlem KaplanNese Colak Ozbey

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