Improvements in patient-reported outcomes: A prospective, non-interventional study with aclidinium bromide for treatment of COPD

Respiratory Medicine
Katharina MarthWolfgang Pohl

Abstract

The inhaled long-acting muscarinic antagonist aclidinium bromide has been shown to significantly improve lung function parameters and symptom severity in patients with COPD in randomised placebo- and active-controlled clinical studies. To obtain a comprehensive view of the treatment effects, patient-reported outcomes were investigated in a real-life COPD population in routine clinical practice in Austria. Multicentre, prospective, non-interventional study in patients with COPD who were newly initiated on treatment with Eklira® Genuair® (aclidinium bromide; recommended dose 400 μg twice daily) as first-line or add-on therapy. Patients were either treatment naïve or switched from other COPD medications. Health-related quality of life by means of the COPD Assessment Test™ (CAT) and symptom-related variables were evaluated at the first visit (baseline) and after approximately 12 weeks of treatment. Features of the inhaler were assessed by patients and physicians at the follow-up visit. A total of 795 COPD patients (56% male; median age: 64 years) were enrolled and treated. During the observational period, the proportion of patients with at least moderate nighttime symptoms, early-morning symptoms, and limitations in morning activit...Continue Reading

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Citations

Mar 11, 2017·Expert Review of Respiratory Medicine·Amanda R van BuulChristian Taube
Apr 5, 2018·Expert Opinion on Drug Discovery·Mario MalerbaPaolo Montuschi
Jan 4, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Amanda R van BuulChristian Taube
Jul 3, 2019·COPD·Helgo MagnussenRoland Greguletz
Feb 23, 2020·NPJ Primary Care Respiratory Medicine·Ioanna Tsiligianni, Janwillem W H Kocks

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