Improvements in productivity and increased participation in daily activities over 52 weeks of certolizumab pegol treatment of rheumatoid arthritis: results of a Belgian observational study

Acta Clinica Belgica
Rene WesthovensLieve Gyselbrecht

Abstract

Objectives: To report changes in productivity and social participation - alongside clinical and patient-reported outcomes (PROs) - in patients with rheumatoid arthritis (RA) receiving certolizumab pegol (CZP) during routine clinical practice in Belgium. Methods: This was a prospective, non-interventional study, in which patients were prescribed CZP at their physicians' discretion and followed during routine clinical visits. The primary outcomes were household productivity and social participation at the last visit (~52 weeks), measured through responses to the Work Productivity Survey. Secondary outcomes included workplace productivity and achievement of DAS28(ESR) clinical response, low disease activity and remission at the last visit. Baseline demographics and adverse events (AEs) were recorded for all patients who received ≥1 dose CZP. Results: A total of 141 patients were enrolled in the study, of whom 119 (84.4%) formed the full analysis set (received ≥1 dose CZP and had ≥1 post-baseline measurement for ≥1 primary outcome). At Visit 1 (baseline), patients reported an average of 11.0 paid work days, 16.8 household work days and 5.5 days of social participation affected by their disease over the previous month. Rapid improve...Continue Reading

References

Jan 1, 1970·Arthritis and Rheumatism·D J McCartyA Gottschalk
Feb 1, 1980·Arthritis and Rheumatism·J F FriesH R Holman
Apr 16, 2003·Annals of the Rheumatic Diseases·H J M VrijhoefSj Van der Linden
Aug 7, 2004·British Journal of Health Psychology·Jolanda De VriesMarjolein Drent
May 17, 2005·Clinical Rheumatology·R WesthovensH Mielants
Apr 7, 2007·Current Opinion in Rheumatology·Arthur Kavanaugh
Dec 25, 2007·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·J LundkvistG Kobelt
Feb 8, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Tracy LiPeter Tugwell
Jul 10, 2012·Current Rheumatology Reports·M Kristen Demoruelle, Kevin D Deane
Jan 11, 2014·Annals of the Rheumatic Diseases·Dörte HuscherUNKNOWN German Collaborative Arthritis Centres
Nov 21, 2014·International Immunology·Claudia MonacoMarc Feldmann
May 6, 2015·BMC Musculoskeletal Disorders·Myrthe van VilsterenJohannes R Anema
Nov 5, 2015·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·T MlcochT Dolezal
Jan 16, 2016·The Journal of Allergy and Clinical Immunology·Minyoung Her, Arthur Kavanaugh
Jan 1, 2015·Reumatologia·Filip RaciborskiBrygida Kwiatkowska
Apr 13, 2017·Reumatología clinica·Diana Rosa-GonçalvesLúcia Costa

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