Improving anti-melanoma effect of curcumin by biodegradable nanoparticles

Oncotarget
Bilan WangYangmei Shen

Abstract

Melanoma is known as the most common malignant cutaneous cancer. Curcumin, a natural component, has been shown to have various activities such as anti-oxidant, anti-septic, anti-inflammatory, anti-biotic, anti-amyloid and anti-thrombosis. However, there is a greatest obstacle in the administration of curcumin due to its hydrophobicity and low oral bioavailability. In this study, we formulated curcumin-loaded MPEG-PLA (Curcumin/MPEG-PLA) micelles aiming to improve its solubility in aqueous solution and investigated anti-tumor effect on melanoma in vitro and in vivo. The spherical curcumin/MPEG-PLA micelles were completely dispersed in normal saline and could release curcumin in a sustained manner in vitro. In addition, we demonstrated that curcumin/MPEG-PLA micelles had stronger cytotoxicity and induced a higher percentage of apoptosis in B16 and A375 cancer cells than free curcumin in vitro. The immunohistochemical study revealed that curcumin/MPEG-PLA micelles induced more melanoma cell apoptosis than free curcumin and inhibited neovascularization in tumor tissues. In conclusion, the curcumin/MPEG-PLA micelles have potential clinical application for melanoma.

References

Apr 4, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Dhananjay DendukuriPatrick S Doyle
Oct 2, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ji Sun ParkKeun-Hong Park
May 21, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Tejaswini S KaleS Thayumanavan
Jun 7, 2011·The New England Journal of Medicine·Caroline RobertJedd D Wolchok
Aug 1, 2012·Nanomedicine·Min SunGuangxi Zhai
Aug 31, 2013·Nutrients·Surangi H Thilakarathna, H P Vasantha Rupasinghe
Oct 12, 2013·ACS Applied Materials & Interfaces·Chien-Shen YangTzu-Wei Wang
Mar 29, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Keru ZhangHaibing He
Jul 6, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Atul KolateAmbikanandan Misra
Jul 17, 2014·Biomaterials·Murali M YallapuSubhash C Chauhan
Oct 26, 2014·Drugs·Kent ShihJeffrey R Infante
Dec 17, 2014·Cancer Letters·Ganji Purnachandra NagarajuBassel F El-Rayes
Jan 16, 2015·Cancer Metastasis Reviews·Anand RotteKevin J McElwee
Jan 28, 2015·Journal of Agricultural and Food Chemistry·Lie-Chwen LinTung-Hu Tsai
Apr 29, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sindhu ThangavelYukio Nagasaki
May 6, 2015·Journal of Hepatology·Jens U MarquardtSnorri S Thorgeirsson
May 30, 2015·Nutrition Reviews·Jessay G DevassyPeter J H Jones
Jun 21, 2015·Trends in Molecular Medicine·Yago Pico de CoañaRolf Kiessling
Jun 30, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Shannon K QuirkDevendra K Agrawal
Jul 15, 2015·Accounts of Chemical Research·Samya Banerjee, Akhil R Chakravarty
Sep 16, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J NaidooJ D Wolchok
Dec 29, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Selma UgurelClaus Garbe
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 15, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J M MichotO Lambotte
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Feb 27, 2016·The International Journal of Biochemistry & Cell Biology·Grażyna MosieniakEwa Sikora
Nov 14, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiang GaoYu-Quan Wei

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Citations

Aug 15, 2019·Nanomedicine·Francisco ArriagadaJavier Morales
Apr 21, 2020·Phytotherapy Research : PTR·Saeedeh Keyvani-GhamsariAsma Gul
May 14, 2021·Pharmaceutical Research·Gayathri Heenatigala PalliyageHarsh Chauhan
Nov 5, 2020·Recent Patents on Anti-cancer Drug Discovery·Saleh A AlmatroodiArshad Husain Rahmani

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Methods Mentioned

BETA
xenograft
Dynamic light scattering
flow cytometry

Software Mentioned

SPSS

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