Improving Assessment of Lipoprotein Profile in Type 1 Diabetes by 1H NMR Spectroscopy

PloS One
Laura BrugnaraAnna Novials

Abstract

Patients with type 1 diabetes (T1D) present increased risk of cardiovascular disease (CVD). The aim of this study is to improve the assessment of lipoprotein profile in patients with T1D by using a robust developed method 1H nuclear magnetic resonance spectroscopy (1H NMR), for further correlation with clinical factors associated to CVD. Thirty patients with T1D and 30 non-diabetes control (CT) subjects, matched for gender, age, body composition (DXA, BMI, waist/hip ratio), regular physical activity levels and cardiorespiratory capacity (VO2peak), were analyzed. Dietary records and routine lipids were assessed. Serum lipoprotein particle subfractions, particle sizes, and cholesterol and triglycerides subfractions were analyzed by 1H NMR. It was evidenced that subjects with T1D presented lower concentrations of small LDL cholesterol, medium VLDL particles, large VLDL triglycerides, and total triglycerides as compared to CT subjects. Women with T1D presented a positive association with HDL size (p<0.005; R = 0.601) and large HDL triglycerides (p<0.005; R = 0.534) and negative (p<0.005; R = -0.586) to small HDL triglycerides. Body fat composition represented an important factor independently of normal BMI, with large LDL particles...Continue Reading

Associated Clinical Trials

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Jul 5, 2017·Diabetology & Metabolic Syndrome·Liene BervoetsPeter Adriaensens
Aug 11, 2020·Cardiovascular Diabetology·Antonio J AmorDidac Mauricio
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Methods Mentioned

BETA
NMR
X-ray
Assay

Software Mentioned

LipoProfile
Cytoscape
regression
PLS
PCN

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