PMID: 16501717Feb 28, 2006Paper

Improving birth dose coverage of hepatitis B vaccine

Bulletin of the World Health Organization
David B HipgraveBeverley-Ann Biggs

Abstract

Administration of a birth dose of hepatitis B vaccine (HepB vaccine) to neonates is recommended to prevent mother-to-infant transmission and chronic infection with the hepatitis B virus (HBV). Although manufacturers recommend HepB vaccine distribution and storage at 2-8 degrees C, recognition of the heat stability of hepatitis B surface antigen stimulated research into its use after storage at, or exposure to, ambient or high temperatures. Storage of HepB vaccine at ambient temperatures would enable birth dosing for neonates delivered at home in remote areas or at health posts lacking refrigeration. This article reviews the current evidence on the thermostability of HepB vaccine when stored outside the cold chain (OCC). The reports reviewed show that the vaccines studied were safe and effective whether stored cold or OCC. Field and laboratory data also verifies the retained potency of the vaccine after exposure to heat. The attachment of a highly stable variety of a vaccine vial monitor (measuring cumulative exposure to heat) on many HepB vaccines strongly supports policies allowing their storage OCC, when this will benefit birth dose coverage. We recommend that this strategy be introduced to improve birth dose coverage, especi...Continue Reading

Citations

Mar 19, 2020·Human Vaccines & Immunotherapeutics·Hong ZhaoYi-Hua Zhou
Jun 6, 2013·International Journal of Hepatology·Muhammad UmarHaider Ali Khan
Jun 9, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·C Wendy Spearman, Mark W Sonderup
Apr 29, 2009·Expert Review of Vaccines·Dexiang Chen, Debra Kristensen
Jan 20, 2018·The Journal of Infectious Diseases·Peyton WilsonSteve R Meshnick
Jan 23, 2018·Open Forum Infectious Diseases·Alastair HeffernanSimon D Taylor-Robinson
Mar 15, 2018·Vaccines·Yaw Asante Awuku, Mary Yeboah-Afihene
Mar 3, 2017·Bulletin of the World Health Organization·Aparna SchweitzerGérard Krause

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