Improving broadband ultrasound attenuation assessment in cancellous bone by mitigating the influence of cortical bone: Phantom and in-vitro study

Ultrasonics
Yuriy TasinkevychJerzy Litniewski

Abstract

The purpose of this work was to present a new approach that allows the influence of cortical bone on noninvasive measurement of broadband ultrasound attenuation (BUA) to be corrected. The method, implemented here at 1 MHz makes use of backscattered signal and once refined and clinically confirmed, it would offer an alternative to ionizing radiation based methods, such as DEXA (Dual-energy X-ray absorptiometry), quantitative computed tomography (QCT), radiographic absorptiometry (RA) or single X-ray absorptiometry (SXA), which are clinically approved for assessment of progress of osteoporosis. In addition, as the method employs reflected waves, it might substantially enhance the applicability of BUA - from being suitable to peripheral bones only it would extend this applicability to include such embedded bones as hip and femoral neck. The proposed approach allows the cortical layer parameters used for correction and the corrected value and parameter of the cancellous bone (BUA) to be determined simultaneously from the single (pulse-echo) bone backscattered wave; to the best of the authors' knowledge such approach was not previously reported. The validity of the method was tested using acoustic data obtained from a custom-designe...Continue Reading

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