Improving Cell Engraftment in Cardiac Stem Cell Therapy

Stem Cells International
Xiaofei LiJianjun Guan

Abstract

Myocardial infarction (MI) affects millions of people worldwide. MI causes massive cardiac cell death and heart function decrease. However, heart tissue cannot effectively regenerate by itself. While stem cell therapy has been considered an effective approach for regeneration, the efficacy of cardiac stem cell therapy remains low due to inferior cell engraftment in the infarcted region. This is mainly a result of low cell retention in the tissue and poor cell survival under ischemic, immune rejection and inflammatory conditions. Various approaches have been explored to improve cell engraftment: increase of cell retention using biomaterials as cell carriers; augmentation of cell survival under ischemic conditions by preconditioning cells, genetic modification of cells, and controlled release of growth factors and oxygen; and enhancement of cell survival by protecting cells from excessive inflammation and immune surveillance. In this paper, we review current progress, advantages, disadvantages, and potential solutions of these approaches.

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Citations

Nov 21, 2019·Journal of Cellular and Molecular Medicine·Lingfei ZhaoJianghua Chen
Mar 15, 2018·Stem Cells International·Heiko LemckeRobert David
Sep 18, 2020·The Biochemical Journal·Peter G ChildsMatthew J Dalby
Oct 2, 2020·Cell Transplantation·Christakis Constantinides
May 27, 2020·Oxidative Medicine and Cellular Longevity·Shaomin YangYuli Huang
Oct 22, 2020·International Journal of Molecular Sciences·Antonia MancusoDonatella Paolino
Apr 21, 2021·Macromolecular Rapid Communications·Chunxiang MoYuping Chen
Aug 31, 2017·ACS Central Science·Hai WangXiaoming He
Feb 27, 2019·ACS Chemical Biology·Ippei TakashimaMotonari Uesugi
Nov 12, 2018·ACS Biomaterials Science & Engineering·Kevin P RobbLauren E Flynn

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