Improving cell engraftment with tissue engineering

Seminars in Thoracic and Cardiovascular Surgery
Erik J SuuronenMarc Ruel

Abstract

Cardiac cell therapy has not yet resulted in long-term clinical benefits or major recovery of myocardial function in humans. To date, most of the cardiac effects of cell-based therapy are believed to be mediated by a local angiogenic response rather than by the formation of neosyncytial contractile units such as had initially been hoped for. Therefore, repopulation of the ischemic or infarcted heart with progenitor cells that have vasculogenic potential may be an important mechanism to improve contractile function, both in the presence of viable and nonviable myocardium. This constitutes a focus within scientific reach; however, the low engraftment and viability of progenitor cells after transplantation necessitate the exploration of novel delivery techniques. Because biomaterials have the capacity to improve cell retention, survival, and differentiation, tissue engineering is now being explored as an approach to support cell-based therapies and enhance their efficacy. In this article, we address current progress made in tissue engineering to support cell therapy for the heart, and summarize our work in the development of biomaterials toward improving cell delivery and vascularization of ischemic tissue.

References

May 1, 1996·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Y M ElçinG Gitnick
Mar 6, 1998·Nature Biotechnology·M ArrasW Schaper
Mar 26, 1999·Journal of Biomaterials Science. Polymer Edition·Y TabataY Ikada
Jul 2, 2002·The Journal of Thoracic and Cardiovascular Surgery·Marc RuelFrank W Sellke
Sep 5, 2002·Journal of Biomedical Materials Research·J S PieperT H van Kuppevelt
Nov 25, 2003·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Andreas H ZischJeffrey A Hubbell
Dec 18, 2003·Clinical and Experimental Pharmacology & Physiology·J J Zwaginga, P Doevendans
Dec 20, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anatoly N LukyanovVladimir P Torchilin
Mar 31, 2004·The Journal of Thoracic and Cardiovascular Surgery·Mauricio A RetuertoTodd K Rosengart
Jul 28, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Jingbo LiuJianyi Zhang
Sep 1, 2004·International Journal of Pharmaceutics·S Freiberg, X X Zhu
Aug 5, 2005·Biotechnology and Bioengineering·Anna BatorskyJan P Stegemann
Sep 15, 2005·Circulation·Keith A RobinsonStephen F Badylak
Jan 26, 2006·Artificial Organs·Pingchuan ZhangShengshou Hu
Feb 25, 2006·The Journal of Clinical Investigation·Hui JinJudy Varner
Jun 24, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Tetsuya IshikawaTakayuki Asahara
Jul 29, 2006·Cell Proliferation·P R SreerekhaL K Krishnan
Mar 21, 2007·World Journal of Surgery·Areck A Ucuzian, Howard P Greisler
May 30, 2007·Archives of Internal Medicine·Ahmed Abdel-LatifBuddhadeb Dawn
Sep 1, 2007·Current Opinion in Cardiology·Amit N Patel, Jorge A Genovese
Nov 6, 2007·Journal of Cellular and Molecular Medicine·Wen Jie ZhangYilin Cao
Nov 21, 2007·The Journal of Thoracic and Cardiovascular Surgery·Eric J VelazquezUNKNOWN STICH Investigators

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Citations

Dec 1, 2010·Journal of Cardiovascular Translational Research·Manuel MazoFelipe Prosper
Mar 18, 2011·Tissue Engineering. Part C, Methods·Raphael GorodetskyWilliam H McBride
Mar 5, 2011·Advanced Drug Delivery Reviews·Zhaoyang YeWensong Tan
Oct 31, 2013·Journal of Tissue Engineering and Regenerative Medicine·Kimberly McEwanErik J Suuronen
Apr 12, 2016·Journal of Tissue Engineering and Regenerative Medicine·Santiago RouraAntoni Bayes-Genis
Mar 23, 2010·Asian Cardiovascular & Thoracic Annals·Olivier SchusslerMarc Ruel
Jul 11, 2012·Cell Transplantation·Caroline CeccaldiBrigitte Sallerin
Apr 2, 2019·Critical Reviews in Biotechnology·Drew KuraitisErik J Suuronen
Apr 11, 2013·Expert Review of Cardiovascular Therapy·Yuelin ZhangHung-Fat Tse
Jul 21, 2011·Journal of Biomaterials Science. Polymer Edition·Kimberly McEwanErik J Suuronen
Jul 25, 2015·Annals of Biomedical Engineering·Priscilla A Williams, Eduardo A Silva
Apr 27, 2019·Journal of Tissue Engineering·Marc DwengerBradley B Keller
Sep 23, 2014·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Nikhil C PandaKenneth R Laurita

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