Improving depression and enhancing resilience in family dementia caregivers: a pilot randomized placebo-controlled trial of escitalopram.

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
Helen LavretskyMichael R Irwin

Abstract

This study examined the potential of an antidepressant drug, escitalopram, to improve depression, resilience to stress, and quality of life in family dementia caregivers in a randomized placebo-controlled double-blinded trial. Forty family caregivers (43-91 years of age, 25 children and 15 spouses; 26 women) who were taking care of their relatives with Alzheimer disease were randomized to receive either escitalopram 10 mg/day or placebo for 12 weeks. Severity of depression, resilience, burden, distress, quality of life, and severity of care-recipient's cognitive and behavioral disturbances were assessed at baseline and over the course of the study. The Hamilton Depression Rating Scale scores at baseline ranged between 10 and 28. The groups were stratified by the diagnosis of major and minor depression. Most outcomes favored escitalopram over placebo. The severity of depression improved, and the remission rate was greater with the drug compared with placebo. Measures of anxiety, resilience, burden, and distress improved on escitalopram compared with placebo. Among caregivers, this small randomized controlled trial found that escitalopram use resulted in improvement in depression, resilience, burden and distress, and quality of l...Continue Reading

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References

Dec 1, 1980·The Gerontologist·S H ZaritJ Bach-Peterson
Sep 27, 1993·Archives of Internal Medicine·B S McEwen, E Stellar
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·J K Kiecolt-GlaserJ Sheridan
Dec 22, 1999·JAMA : the Journal of the American Medical Association·R Schulz, S R Beach
Sep 7, 2000·The British Journal of Psychiatry : the Journal of Mental Science·A MarriottA Burns
Jun 1, 2002·The Gerontologist·Silvia SörensenPaul Duberstein
Sep 28, 2002·The Gerontologist·Richard SchulzAlan Stevens
Apr 2, 2003·Psychiatry and Clinical Neurosciences·Takashi Hosaka, Yoko Sugiyama
Aug 26, 2003·The Gerontologist·Carl EisdorferJosé Szapocznik
Sep 10, 2003·Depression and Anxiety·Kathryn M Connor, Jonathan R T Davidson
Jan 1, 1959·The British Journal of Medical Psychology·M HAMILTON
May 4, 2004·The American Journal of Psychiatry·Mary S MittelmanWilliam E Haley
May 6, 2004·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Richard Schulz, Lynn M Martire
Oct 30, 2004·The American Journal of Psychiatry·Steven P RooseUNKNOWN Old-Old Depression Study Group
May 25, 2005·Human Psychopharmacology·M LaderT Baekdal
Jul 20, 2005·Journal of Clinical Psychopharmacology·Steven P Roose, Alan F Schatzberg
Aug 10, 2005·The Journal of Clinical Psychiatry·Helen LavretskyAnand Kumar
Dec 6, 2005·The Psychiatric Clinics of North America·Richard SchulzJulie N Klinger
Apr 4, 2006·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Alan Schatzberg, Steven Roose
May 12, 2006·International Psychogeriatrics·Martin Pinquart, Silvia Sörensen
Apr 28, 2007·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Helen LavretskyAnand Kumar
Jan 1, 2008·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·F Andrew KozelA John Rush
May 6, 2008·Journal of Psychiatric Research·Amanda J LamondDilip V Jeste

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Citations

Jul 10, 2014·International Psychogeriatrics·Ji Won HanKi Woong Kim
Jan 28, 2010·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Constantine G Lyketsos
Jul 18, 2016·Comprehensive Psychiatry·Vilmantė PakalniškienėJan Hilbig
Apr 21, 2016·Critical Care Medicine·Peter D SottileMarc Moss
Aug 18, 2016·JBI Database of Systematic Reviews and Implementation Reports·Andrea PetriwskyjNikki Nucifora
Dec 20, 2016·Arquivos de neuro-psiquiatria·Rachel DiasMarcia Cristina Nascimento Dourado
Apr 11, 2015·Trends in psychiatry and psychotherapy·Rachel DiasMarcia Cristina Nascimento Dourado
Nov 20, 2018·Aging & Mental Health·Warren J DonnellanLaura K Soulsby
Jan 5, 2013·Neurology India·Shyamal K DasMalay K Ghosal
Mar 20, 2014·Sociology of Health & Illness·John L OliffeHarriet MacMillan
Dec 14, 2019·The American Journal of Hospice & Palliative Care·Carolina Palacio GJoaquín T Limonero
Jul 13, 2012·The Cochrane Database of Systematic Reviews·Andrea CiprianiCorrado Barbui
Aug 25, 2015·World Journal of Clinical Cases·Miquel Baquero, Nuria Martín
Aug 16, 2016·Critical Care Medicine·Peter D Sottile, Marc Moss
Dec 12, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Carolina Palacio, Joaquín T Limonero
May 29, 2013·Current Psychiatry Reports·Todd J RichardsonGeorge T Grossberg
Dec 1, 2018·The Journal of Nutrition, Health & Aging·R M Guimarães
Jun 20, 2020·Journal of Geriatric Psychiatry and Neurology·Nathália R S KimuraMarcia C N Dourado

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