Improving external beam radiotherapy by combination with internal irradiation

The British Journal of Radiology
A DietrichMechthild Krause

Abstract

The efficacy of external beam radiotherapy (EBRT) is dose dependent, but the dose that can be applied to solid tumour lesions is limited by the sensitivity of the surrounding tissue. The combination of EBRT with systemically applied radioimmunotherapy (RIT) is a promising approach to increase efficacy of radiotherapy. Toxicities of both treatment modalities of this combination of internal and external radiotherapy (CIERT) are not additive, as different organs at risk are in target. However, advantages of both single treatments are combined, for example, precise high dose delivery to the bulk tumour via standard EBRT, which can be increased by addition of RIT, and potential targeting of micrometastases by RIT. Eventually, theragnostic radionuclide pairs can be used to predict uptake of the radiotherapeutic drug prior to and during therapy and find individual patients who may benefit from this treatment. This review aims to highlight the outcome of pre-clinical studies on CIERT and resultant questions for translation into the clinic. Few clinical data are available until now and reasons as well as challenges for clinical implementation are discussed.

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Citations

Feb 16, 2016·Advanced Drug Delivery Reviews·Mechthild KrauseMichael Baumann
Jul 15, 2015·The British Journal of Radiology·C von NeubeckM Krause
Aug 16, 2016·The British Journal of Radiology·Aurélien Corroyer-DulmontKatherine A Vallis
May 27, 2016·Biomarkers in Cancer·Katherine ZukotynskiFrederic Fahey
Aug 17, 2018·Molecular Cancer·Virgínea de Araujo FariasJosé Mariano Ruiz de Almodóvar
Nov 24, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Antje DietrichMechthild Krause
May 25, 2021·Nuclear Medicine and Biology·Shishu Kant SumanArchana Mukherjee
Jun 14, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Antje DietrichMechthild Krause

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