Improving GRADE evidence tables part 2: a systematic survey of explanatory notes shows more guidance is needed

Journal of Clinical Epidemiology
Miranda W LangendamH J Schünemann

Abstract

The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) working group has developed GRADE evidence profiles (EP) and summary of findings (SoF) tables to present evidence summaries in systematic reviews, clinical guidelines, and health technology assessments. Explanatory notes are used to explain choices and judgments in these summaries, for example, on rating of the quality of evidence. A systematic survey of the explanations in SoF tables in 132 randomly selected Cochrane Intervention reviews and in EPs of 10 guidelines. We analyzed the content of 1,291 explanations using a predefined list of criteria. Most explanations were used to describe or communicate results and to explain downgrading of the quality of evidence, in particular for risk of bias and imprecision. Addressing the source of baseline risk (observational data or control group risk) was often missing. For judgments about downgrading the quality of evidence, the percentage of informative explanations ranged between 41% (imprecision) and 79% (indirectness). We found that by and large explanations were informative but detected several areas for improvement (e.g., source of baseline risk and judgments on imprecision). Guidance about explanatory ...Continue Reading

References

Dec 22, 2006·The Lancet Infectious Diseases·Holger J SchünemannUNKNOWN WHO Rapid Advice Guideline Panel on Avian Influenza
May 4, 2010·Journal of Clinical Epidemiology·Sarah E RosenbaumAndrew D Oxman
Sep 8, 2010·The Journal of Allergy and Clinical Immunology·Jan L BrozekUNKNOWN Grading of Recommendations Assessment, Development and Evaluation Working Group
Jan 5, 2011·Journal of Clinical Epidemiology·Gordon GuyattHolger J Schünemann
Jan 21, 2011·Journal of Clinical Epidemiology·Gordon H GuyattHolger J Schünemann
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis
Aug 2, 2011·Journal of Clinical Epidemiology·Gordon H GuyattUNKNOWN GRADE Working Group
Aug 2, 2011·Journal of Clinical Epidemiology·Gordon H GuyattUNKNOWN GRADE Working Group
Aug 2, 2011·Journal of Clinical Epidemiology·Gordon H GuyattHolger J Schünemann
Aug 2, 2011·Journal of Clinical Epidemiology·Gordon H GuyattUNKNOWN GRADE Working Group
Aug 16, 2011·Journal of Clinical Epidemiology·Gordon H GuyattHolger J Schünemann
May 23, 2012·Journal of Clinical Epidemiology·Gordon H GuyattHolger J Schünemann
Apr 30, 2013·Journal of Clinical Epidemiology·Reem A MustafaHolger J Schünemann
Sep 26, 2013·Systematic Reviews·Miranda W LangendamHolger J Schünemann
Oct 17, 2013·Indian Journal of Pharmacology·Shashank Deoghare

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Citations

Apr 30, 2016·Environment International·Kristina A Thayer, Holger J Schünemann
Jul 15, 2018·Research Synthesis Methods·Yuan ZhangHolger J Schünemann
Mar 15, 2019·JBI Database of Systematic Reviews and Implementation Reports·Holger J SchünemannJan L Brozek
Jun 7, 2020·Health and Quality of Life Outcomes·Tejan BaldehHolger J Schünemann
Jul 14, 2021·Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen·Olesja RisslingLukas Schwingshackl

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