Abstract
Hashimoto's thyroiditis (HT) is a common autoimmune disorder that causes significant morbidity. Interleukin (IL)-17 was identified as a major contributing factor in the pathogenesis of HT. Blastocystis hominis (BH) is a very common infection and has been shown to be associated with several diseases. Our aim was to determine serum IL-17 level in HT patients with and without BH infection and the effect of eradicating BH in patients with HT. A prospective cohort study was conducted on 20 HT patients not infected with BH (group I), 20 HT patients infected with BH (group II), and 20 healthy patients (group III). Serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), thyroid peroxidase antibodies (anti-TPO), and IL-17 were performed by ELISA method and were repeated in group II after 6 weeks of eradication of BH. Patients with HT showed a significantly higher serum IL-17 compared with controls. IL-17 was significantly higher in HT patients infected with BH compared with HT patients not BH infected (mean 6.93 ± 2.83 pg/ml versus 3.25 ± 1.55 pg/ml, p = 0.003). After BH eradication TSH, anti-TPO, and IL-17 were significantly decreased (mean 14.76 ± 11.11 µIU/ml versus 9.39 ± 7.11 µIU/ml, p < 0.001; m...Continue Reading
References
Jan 5, 2002·Acta Tropica·Hande DagciSeza Budak
Jan 5, 2002·Parasitology Research·H Y LongA Ambrosch
Apr 15, 2006·The Journal of Endocrinology·Alicia J KlechaGraciela A Cremaschi
Jun 2, 2012·Current Genomics·Katja Zaletel, Simona Gaberšček
Nov 12, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Dapeng LiBo Huang
May 9, 2014·Tropical Medicine and Health·Ahmed I Youssef, Shoji Uga
Aug 27, 2014·Infection and Immunity·Mei Xing LimYongliang Zhang
Aug 1, 2015·Journal of Infection in Developing Countries·Borko RajičSuzana Maslać
Mar 2, 2016·Cytokine·Ceyla Konca DegertekinMetin Arslan
Apr 7, 2016·Mediators of Inflammation·Antonio ManciniDiego Currò
Jul 4, 2017·Indian Journal of Endocrinology and Metabolism·Fatemeh EsfahanianZohreh Jadali
Nov 21, 2018·Clinical Case Reports·Magdy Mohamed Allam, Hanaa Tarek Hussein Elzawawy
Apr 20, 2019·Epidemiology and Health·Shabnam AsfaramMehdi Sharif
Jun 1, 2019·Acta Endocrinologica : the International Journal of the Romanian Society of Endocrinology·J GerenovaS Stanilova