Improving hemodynamics of cardiovascular system under a novel intraventricular assist device support via modeling and simulations

Computer Assisted Surgery
Shidong ZhuXiaohao Wang

Abstract

Ventricular assist devices (LVADs) are increasingly recognized for supporting blood circulation in heart failure patients who are non-transplant eligible. Because of its volume, the traditional pulsatile device is not easy to implant intracorporeally. Continuous flow LVADs (CF-LVADs) reduce arterial pulsatility and only offer continuous flow, which is different from physiological flow, and may cause long-term complications in the cardiovascular system. The aim of this study was to design a new pulsatile assist device that overcomes this disadvantage, and to test this device in the cardiovascular system. Firstly, the input and output characteristics of the new device were tested in a simple cardiovascular mock system. A detailed mathematical model was established by fitting the experimental data. Secondly, the model was tested in four pathological cases, and was simulated and coupled with a fifth-order cardiovascular system and a new device model using Matlab software. Using assistance of the new device, we demonstrated that the left ventricle pressure, aortic pressure, and aortic flow of heart failure patients improved to the levels of a healthy individual. Especially, in state IV level heart failure patients, the systolic bloo...Continue Reading

References

Jun 1, 1988·Circulation·D A Kass, W L Maughan
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·M Ursino, E Magosso
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·M Ursino, E Magosso
Aug 5, 2000·Perfusion·H M Reul, M Akdis
May 26, 2001·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Y C YuJ F Antaki
Jun 13, 2002·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Guruprasad A GiridharanGeorge M Pantalos
Jun 30, 2009·Artificial Organs·Lieke G E CoxFrans N van de Vosse
Feb 23, 2010·IEEE Transactions on Bio-medical Engineering·Taco KindMichel Verhaegen
May 8, 2013·Artificial Organs·Ashraf William Khir, Gianpaolo Bruti
Mar 13, 2014·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Feng HuangXin Fu
Jun 28, 2014·The International Journal of Artificial Organs·Selim BozkurtMarcel C M Rutten
Nov 1, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Mohamed ZeriouhAron-Frederik Popov
Jun 30, 2016·Expert Review of Medical Devices·Johannes WappenschmidtAndreas Goetzenich
Jul 29, 2016·Annals of Biomedical Engineering·Johannes WappenschmidtAndreas Goetzenich

❮ Previous
Next ❯

Citations

Feb 12, 2019·Computer Assisted Surgery·Shidong ZhuXiaohao Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Zhiming SongYi Zeng
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Santiago GarciaRanjit John
© 2022 Meta ULC. All rights reserved