Improving lactose digestion and symptoms of lactose intolerance with a novel galacto-oligosaccharide (RP-G28): a randomized, double-blind clinical trial

Nutrition Journal
Dennis A SavaianoHoward L Foyt

Abstract

Lactose intolerance (LI) is a common medical problem with limited treatment options. The primary symptoms are abdominal pain, diarrhea, bloating, flatulence, and cramping. Limiting dairy foods to reduce symptoms contributes to low calcium intake and the risk for chronic disease. Adaptation of the colon bacteria to effectively metabolize lactose is a novel and potentially useful approach to improve lactose digestion and tolerance. RP-G28 is novel galacto-oligosaccharide (GOS) being investigated to improve lactose digestion and the symptoms of lactose intolerance in affected patients. A randomized, double-blind, parallel group, placebo-controlled study was conducted at 2 sites in the United States. RP-G28 or placebo was administered to 85 patients with LI for 35 days. Post-treatment, subjects reintroduced dairy into their daily diets and were followed for 30 additional days to evaluate lactose digestion as measured by hydrogen production and symptom improvements via a patient-reported symptom assessment instrument. Lactose digestion and symptoms of LI trended toward improvement on RP-G28 at the end of treatment and 30 days post-treatment. A reduction in abdominal pain was also demonstrated in the study results. Fifty percent of R...Continue Reading

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Citations

Dec 30, 2015·Critical Reviews in Food Science and Nutrition·M CorgneauC Gaiani
Dec 19, 2018·Nutrients·Andrew Szilagyi, Norma Ishayek
Mar 26, 2019·Annual Review of Food Science and Technology·Todd Robert Klaenhammer
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Nov 14, 2019·Nutrients·Enrique Romero-VelardeJan Geurts
Jan 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·M Andrea Azcarate-PerilTodd R Klaenhammer
Jun 6, 2017·Frontiers in Microbiology·Min ZhengAloysius Wong
Aug 23, 2020·Nutrients·Simona DraganRuxandra Christodorescu
Nov 12, 2020·The Journal of Experimental Medicine·Allyson L ByrdUNKNOWN Milieu Intérieur Consortium
Jun 3, 2021·Nutrients·Domenico GarganoPaola Iovino

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