Abstract
Exploiting the solid-state drawing (SSD) process toward polymer materials for medical implant devices is of significance to simultaneously improve the mechanical property and biocompatibility. Herein, for the first time, the bionic implants with a microvalley surface of oriented long chain branching PLA (b-PLA) was fabricated by a feasible SSD process. The as-obtained b-PLAs could not only show a high tensile strength (278.1 MPa) and modulus (4.32 GPa) but also bear a superior protein adsorption as high as 622 ng/cm2. Such exceptional mechanical properties and biocompatibility could be ascribed to the SSD process-induced highly orientation degree and the morphology of parallel grooves within ridges structures, resulting in the greatly enhanced crystallinity and surface hydrophobicity as well as a biocompatible vascular endothelial microstructure for cell to adhesion and growth and thus an improved proliferation, differentiation, and activity of osteoblasts with spindle-shaped and spread morphology on surface of the b-PLAs. These findings may pave the way for designing the novel biomaterials for vascular stent or tissue engineering devices by the SSD process.
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Citations
Jan 26, 2021·ACS Applied Materials & Interfaces·Jiafeng LiLu Cao
Jan 20, 2021·ACS Biomaterials Science & Engineering·Wancheng ZhuYashao Chen
Sep 18, 2020·ACS Applied Materials & Interfaces·Fumio AsaiYukikazu Takeoka
Aug 28, 2021·Biofabrication·Shaohua WuShaojuan Chen