Improving medication adherence among kidney transplant recipients: Findings from other industries, patient engagement, and behavioral economics-A scoping review

SAGE Open Medicine
Shelley R OberlinTimothy L Pruett

Abstract

The immune system is a powerful barrier to successful organ transplantation, but one that has been routinely thwarted through modern pharmacotherapeutics. Despite the benefits of immunosuppressive therapy, medication non-adherence leads to an increased risk of graft rejection, higher hospital utilization and costs, and poor outcomes. We conduct a scoping review following Arksey and O'Malley's five-stage framework methodology to identify established or novel interventions that could be applied to kidney transplant recipients to improve medication adherence. As the desired outcome is a behavior (taking a pill), we assess three areas: behavioral-focused interventions in other industries, patient engagement theories, and behavioral economic principles. Search strategies included mining business, social sciences, and medical literature with additional guidance from six consultative interviews. Our review suggests that no intervention stands out as superior or likely to be more effective than any other intervention; yet promising strategies and interventions were identified across all three areas examined. Based on our findings, we believe there are five strategies that transplant centers and other organizations can implement to impr...Continue Reading

References

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Citations

Mar 9, 2017·Canadian Journal of Kidney Health and Disease·Mirela MaierRuth Sapir-Pichhadze
Nov 13, 2018·Current Transplantation Reports·Mary Amanda DewAnnette J DeVito Dabbs
Mar 30, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Elizabeth A SteinbergJens Goebel
Apr 19, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·James TangAllison Tong

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Methods Mentioned

BETA
chips
X-ray

Software Mentioned

Turbo
NudgerSize
MNCAT

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