Improving Newborn Respiratory Outcomes With a Sustained Inflation: A Systematic Narrative Review of Factors Regulating Outcome in Animal and Clinical Studies

Frontiers in Pediatrics
Calista J LambertErin V McGillick

Abstract

Respiratory support is critically important for survival of newborns who fail to breathe spontaneously at birth. Although there is no internationally accepted definition of a sustained inflation (SI), it has commonly been defined as a positive pressure inflation designed to establish functional residual capacity and applied over a longer time period than normally used in standard respiratory support (SRS). Outcomes vary distinctly between studies and to date there has been no comprehensive investigation of differences in SI approach and study outcome in both pre-clinical and clinical studies. A systematic literature search was performed and, after screening, identified 17 animal studies and 17 clinical studies evaluating use of a SI in newborns compared to SRS during neonatal resuscitation. Study demographics including gestational age, SI parameters (length, repetitions, pressure, method of delivery) and study outcomes were compared. Animal studies provide mechanistic understanding of a SI on the physiology underpinning the cardiorespiratory transition at birth. In clinical studies, there is considerable difference in study quality, delivery of SIs (number, pressure, length) and timing of primary outcome evaluation which limits...Continue Reading

References

Mar 6, 2004·Seminars in Neonatology : SN·Steven M Donn, Sunil K Sinha
May 3, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·A E HarlingC W Yoxall
Mar 17, 2009·Respiratory Research·Megan J WallaceStuart B Hooper
Jul 12, 2012·Archives of Disease in Childhood. Fetal and Neonatal Edition·Claus KlingenbergStuart B Hooper
Jul 23, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Noah H HillmanAlan H Jobe
Mar 15, 2014·Reproductive Health·Hannah BlencoweUNKNOWN Born Too Soon Preterm Birth Action Group
Jan 28, 2015·Pediatrics·Gianluca ListaUNKNOWN SLI Trial Investigators
Jan 31, 2015·Journal of Applied Physiology·David G TingayJ Jane Pillow
May 20, 2015·Anesthesia and Analgesia·Hannah C GlassPeter J Davis
Jul 2, 2015·The Cochrane Database of Systematic Reviews·Colm Pf O'DonnellSimona Zappettini
Jul 18, 2015·American Journal of Respiratory Cell and Molecular Biology·David G TingayPeter G Davis
Sep 27, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·David G TingayPeter G Davis
Nov 7, 2015·Archives of Disease in Childhood. Fetal and Neonatal Edition·Stuart B HooperMarcus J Kitchen
Jan 29, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·D MercadanteF Mosca
Jul 8, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mohamed S El-ChimiDina M Shinkar
Nov 25, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·David G TingayPeter G Davis
Jun 10, 2017·Archives of Disease in Childhood. Fetal and Neonatal Edition·Ashley Y NganGeorg M Schmölzer
Oct 22, 2017·Archives of Disease in Childhood. Fetal and Neonatal Edition·Jessica R CrawshawStuart B Hooper
Dec 30, 2017·Journal of Neonatal-perinatal Medicine·N Abd El-FattahMohammed Khashaba
Jul 28, 2018·Archives of Disease in Childhood. Fetal and Neonatal Edition·Tessa MartherusArjan B Te Pas
Feb 8, 2019·American Journal of Respiratory and Critical Care Medicine·David G TingayPeter A Dargaville
Mar 16, 2019·American Journal of Respiratory and Critical Care Medicine·Martin Keszler
Apr 18, 2019·American Journal of Respiratory Cell and Molecular Biology·Prue M Pereira-FantiniDavid G Tingay

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Methods Mentioned

BETA
lavage
X-ray
bronchoalveolar

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