Improving of bowel cleansing effect for polyethylene glycol with ascorbic acid using simethicone: A randomized controlled trial

Medicine
In Kyung YooChang Duck Kim

Abstract

Low-volume polyethylene glycol with ascorbic acid (PEG-Asc) use is reported to be as safe and effective as traditional 4-L polyethylene glycol use. However, PEG-Asc produces bubbles, which cause problems during colonoscopy. Data on the effects of using antifoaming agents such as simethicone with PEG-Asc are lacking. The aim of this CONSORT-prospective, randomized, observer-blinded, controlled trial is to compare the quality of bowel preparation and compliance between PEG-Asc users and PEG-Asc plus simethicone users. Adult outpatients aged 18 to 80 years undergoing colonoscopy were recruited to the study. Two hundred sixty patients were randomly assigned to 1 of 2 treatment arms, PEG-Asc or PEG-Asc plus simethicone. The primary outcome measure was the bowel cleansing quality using Boston bowel preparation scale and bubble scores. The secondary outcome measures were patient tolerability and doctor tolerability. The simethicone group showed superior cleansing results (6-9 Boston scale scores: 99% vs. 84%, <5% bubble scores: 96% vs. 49%, P < 0.001) and fewer gastrointestinal symptoms (abdominal fullness: 24% vs. 55%, colicky pain: 5% vs. 24%, P < 0.001) than the non-simethicone group. Moreover, endoscopist fatigue during colonoscop...Continue Reading

References

Feb 1, 1988·Digestive Diseases and Sciences·W A ShaverW L Peterson
May 1, 1994·Journal of Applied Toxicology : JAT·L BrecevićF Strajnar
Apr 29, 1998·JAMA : the Journal of the American Medical Association·S R DaughertyB D Rowley
Oct 26, 1999·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·M T SteeleR L Muelleman
Mar 28, 2006·Gastrointestinal Endoscopy·Douglas K RexIrving M Pike
May 9, 2006·Gastroenterology·George F LongstrethRobin C Spiller
Nov 17, 2007·The American Journal of Gastroenterology·Wei WeiShu-Dong Xiao
Jan 13, 2009·Gastrointestinal Endoscopy·Edwin J LaiBrian C Jacobson
Jun 26, 2009·World Journal of Gastroenterology : WJG·Sasinee TongprasertSasivimol Rattanasiri
Sep 9, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Cristiano SpadaGuido Costamagna
Jul 7, 2010·Scandinavian Journal of Gastroenterology·Sietske CorporaalJan J Koornstra
Jan 14, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Cesare HassanAlessandro Repici
Sep 18, 2013·World Journal of Gastrointestinal Endoscopy·Annalisa de LeoneCristiano Crosta
Dec 4, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·In Kyung YooHo Sang Ryu

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Citations

May 3, 2019·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Yuanfa LiDou Fu
Mar 30, 2018·Journal of the Canadian Association of Gastroenterology·Amine Benmassaoud, Josée Parent
Apr 13, 2019·Digestive Diseases and Sciences·Haewon KimMoon Sung Lee
Dec 8, 2020·Endoscopy·Filipe TaveiraMiguel Areia
May 29, 2021·World Journal of Clinical Cases·Hu ZhangHeng Zhang

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NCT02548403

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