Improving outcomes in depression: a focus on somatic symptoms

Journal of Psychosomatic Research
Roger S McIntyreSidney H Kennedy

Abstract

It is hypothesized that somatic symptom alleviation is a significant predictor of overall outcome in depressed primary care patients. Depressed primary care patients (N=205) meeting DSM-IV-TR criteria received open-label antidepressant therapy. The primary symptom measurement tool used was the 17-item Hamilton Depression Rating Scale (HAMD-17), with the Montgomery-Asberg Depression Rating Scale (MADRS) and the Clinical Global Impression Improvement/Severity (CGI-I/S) used as secondary measures. As proxies for somatic symptoms, 8 items from the HAMD-17 (HAMD-S) and 3 items from the MADRS (MADRS-S) that measure somatic symptoms were identified and extracted. There was a significant correlation between improvement on the HAMD-S score and overall reduction on the MADRS total score (r=.766, P<.001), response (r=.594, P<.001), and remission (r=.552, P<.001). Improvement on the MADRS-S also correlated with overall HAMD-17 improvement (r=.782, P<.001), along with response (r=.649, P<.001) and remission (r=.539, P<.001) rates. Both the HAMD-S and the MADRS-S correlated with global improvement as measured by the CGI-I/S (P<.001). A reciprocal interaction between somatic symptoms and other depressive-symptom domains is implied by this ana...Continue Reading

References

May 7, 1992·The New England Journal of Medicine·M B MaxR Dubner
Jan 1, 1987·Journal of Psychosomatic Research·G Mendelson
Jan 1, 1974·Behavioral Science·L R DerogatisL Covi
Nov 1, 1995·Psychological Medicine·E S PaykelA Barocka
Apr 30, 1999·The Journal of Clinical Psychiatry·A A NierenbergM Fava
Oct 28, 1999·The New England Journal of Medicine·G E SimonJ Ormel
Sep 29, 2000·The American Journal of Psychiatry·P F SullivanK S Kendler
Nov 4, 2000·Psychopathology·E Corruble, J D Guelfi
May 10, 2002·The Journal of Clinical Psychiatry·Maurizio Fava
Jun 19, 2003·JAMA : the Journal of the American Medical Association·Ronald C KesslerUNKNOWN National Comorbidity Survey Replication
Aug 11, 2004·Human Psychopharmacology·Roger S McIntyreLakshmi N Yatham
Oct 7, 2004·The American Journal of Psychiatry·Mark ZimmermanIwona Chelminski
Feb 8, 2005·General Hospital Psychiatry·Linda H HarpoleJürgen Unützer
May 14, 2005·The Journal of Clinical Psychiatry·Jordan F KarpEllen Frank
Nov 23, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Roger S McIntyreSidney H Kennedy

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Citations

Jan 17, 2009·Issues in Mental Health Nursing·Evelyn Parrish, Ann Peden
Sep 3, 2011·The Journal of Sexual Medicine·Louis F Fabre, Louis C Smith
Feb 22, 2011·Journal of Psychosomatic Research·Cory P Lehoux, Frances V Abbott
Aug 25, 2009·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Mark I WeinbergerMartha L Bruce
Nov 2, 2013·Journal of Affective Disorders·Ya-Mei BaiMu-Hong Chen
Feb 19, 2008·Journal of Affective Disorders·Anthony L VaccarinoAmir H Kalali
Jul 31, 2013·Journal of Affective Disorders·Chris BaekenRudi De Raedt
Dec 17, 2008·Psychosomatic Medicine·Anthony L VaccarinoAmir H Kalali
Sep 18, 2007·Journal of Clinical Psychopharmacology·Daniel HarnackAndreas Ströhle
Jul 26, 2007·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Jorge M TamayoRodrigo Muñoz
Aug 12, 2021·JAMA Psychiatry·Brittany L MitchellEnda M Byrne

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