Improving patient selection for 18F-FDG PET scanning in the staging of gastric cancer

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Yui KanekoCuong Duong

Abstract

Standard pretreatment staging for gastric cancer includes CT of the chest, abdomen, and pelvis; gastroscopy; and laparoscopy. Although (18)F-PET combined with CT has proven to be a useful staging tool in many cancers, some gastric cancers are not (18)F-FDG-avid and its clinical value is still debatable. Gastric cancer patients who underwent staging (18)F-FDG PET scans from 2002 to 2013 at the Peter MacCallum Cancer Center were retrospectively analyzed, and a systematic review was also conducted using PubMed between 2000 to March 2014 to investigate clinicopathologic parameters associated with (18)F-FDG avidity. A pretreatment PET scoring system was developed from predictors of (18)F-FDG avidity. Both the retrospective analysis of the patients and the systematic literature review showed similar significant predictors of (18)F-FDG avidity, including large tumor size, non-signet ring cell carcinoma type, and glucose transporter 1-positive expression on immunohistochemistry. A PET scoring system was developed from these clinicopathologic parameters that allowed (18)F-FDG-avid tumors to be detected with a sensitivity of 85% and a specificity of 71%. A pretreatment PET scoring system can assist in the selection of patients with gastr...Continue Reading

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Citations

Oct 22, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Pierre-Yves Le RouxRodney J Hicks
Dec 23, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M Martin-RichardA Carrato
Feb 23, 2019·The British Journal of Radiology·Alicia S BorggreveJelle P Ruurda
Apr 8, 2018·Annals of Surgical Oncology·Michihiro KudouEigo Otsuji
Dec 19, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Soo Jeong KimKyung-Han Lee
Aug 31, 2021·Nuclear Medicine Communications·Francesco DondiFrancesco Bertagna

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