Improving PET/MR brain quantitation with template-enhanced ZTE

NeuroImage
Gaspar DelsoTetsuro Sekine

Abstract

The impact of MR-based attenuation correction on PET quantitation accuracy is an ongoing cause of concern for advanced brain research with PET/MR. The purpose of this study was to evaluate a new, template-enhanced zero-echo-time attenuation correction method for PET/MR scanners. 30 subjects underwent a clinically-indicated 18F-FDG-PET/CT, followed by PET/MR on a GE SIGNA PET/MR. For each patient, a 42-s zero echo time (ZTE) sequence was used to generate two attenuation maps: one with the standard ZTE segmentation-based method; and another with a modification of the method, wherein pre-registered anatomical templates and CT data were used to enhance the segmentation. CT data, was used as gold standard. Reconstructed PET images were qualified visually and quantified in 68 volumes-of-interest using a standardized brain atlas. Attenuation maps were successfully generated in all cases, without manual intervention or parameter tuning. One patient was excluded from the quantitative analysis due to the presence of multiple brain metastases. The PET bias with template-enhanced ZTE attenuation correction was measured to be -0.9% ± 0.9%, compared with -1.4% ± 1.1% with regular ZTE attenuation correction. In terms of absolute bias, the new...Continue Reading

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Citations

Oct 22, 2019·The American Journal of Sports Medicine·Ryan E BreighnerHollis G Potter
May 27, 2020·Clinical Nuclear Medicine·Tetsuya TsujikawaHidehiko Okazawa
Aug 7, 2020·EJNMMI Physics·Johanna HarriesBernhard Sattler
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Apr 9, 2021·Topics in Magnetic Resonance Imaging : TMRI·Mark SmithMai-Lan Ho
Apr 14, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ahmadreza RezaeiJohan Nuyts

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