Improving Properties of Albendazole Desmotropes by Supramolecular Systems with Maltodextrin and Glutamic Acid

AAPS PharmSciTech
Agustina BongioanniClaudia Garnero

Abstract

Albendazole, an effective broad-spectrum anthelmintic agent, showed unpredictable therapeutic response caused by poor water solubility and slow dissolution rate. Then, novel binary and multicomponent supramolecular systems of two different solid forms of albendazole (I and II) with maltodextrin alone or with glutamic acid were studied as an alternative to improve the oral bioavailability of albendazole. The interactions and effects on the properties of albendazole were studied in solution and solid state. The solid systems were characterized using Raman and Fourier transform-infrared spectroscopy, thermal analysis, powder X-ray diffraction, and scanning electron microscopy. The solubility measurements, performed in aqueous and simulated gastric fluid, showed that albendazole (form II) was the most soluble form, while its supramolecular systems showed the highest solubility in simulated gastric fluid. On the other hand, the dissolution profiles of binary and multicomponent systems in simulated gastric fluid displayed pronounced increments of the dissolved drug and a faster dissolution rate compared to those of free albendazole forms. Thus, these supramolecular structures constitute an interesting alternative to improve the physi...Continue Reading

References

May 30, 2001·International Journal of Pharmaceutics·P Costa
Jul 5, 2003·International Journal of Pharmaceutics·Paola MuraMarzia Cirri
Aug 7, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Marc LindenbergJ B Dressman
Jun 5, 2007·European Journal of Medicinal Chemistry·Gladys E GraneroMarcela R Longhi
Jan 30, 2010·Journal of Pharmaceutical Sciences·Marco B PranzoRuggero Bettini
Mar 30, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·María G BarreraMaría Celina Lamas
Oct 13, 2011·Journal of Pharmaceutical Sciences·Harry G Brittain
Jan 15, 2015·Molecular Pharmaceutics·Ana K ChattahClaudia Garnero
Jan 16, 2016·International Journal of Pharmaceutics·Laura Martinez-MarcosGavin W Halbert
Mar 23, 2017·Carbohydrate Polymers·Ana K ChattahClaudia Garnero

Citations

Methods Mentioned

BETA
differential
X-Ray

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Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.