Improving response and outcomes for patients with liver-limited metastatic colorectal cancer

Clinical Colorectal Cancer
David J Gallagher, Nancy E Kemeny

Abstract

Long-term survival with colorectal liver metastases (CLM) usually requires surgical resection, despite considerable improvements in systemic chemotherapy that have extended median survival with metastatic colorectal cancer from 6 months to in excess of 2 years. Multidisciplinary management is now the norm in the perioperative setting, and chemotherapy has become part of an accepted treatment paradigm. Systemic and intrahepatic chemotherapy can shrink inoperable disease to the point of resection, and a combination of neoadjuvant and adjuvant chemotherapy improves disease-free survival for patients with operable CLM. A greater understanding of the biology of colorectal metastasis has revealed many new potential targets, and carefully designed clinical trials are required to investigate these and other existing biologic therapies in this setting. In this article we discuss the biology of colorectal cancer metastases, the rationale for perioperative chemotherapy, and the recent and ongoing investigation of perioperative chemotherapy in the management of CLM.

References

Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G PosteI J Fidler
Aug 12, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S GiacchettiF Lévi
Sep 3, 1999·Journal of the American College of Surgeons·S IwatsukiT E Starzl
Oct 11, 2001·Clinical & Experimental Metastasis·S PakuJ Timár
Feb 15, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B GrayV Gebski
May 30, 2002·Annals of Surgery·Michael A ChotiJohn L Cameron
Aug 3, 2002·Nature Reviews. Cancer·Ann F ChambersIan C MacDonald
Jun 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Oleg Schmidt-KittlerChristoph A Klein
Dec 17, 2003·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·David A KoobyWilliam R Jarnagin
May 21, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C PozzoC Barone
Jan 29, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T DelaunoitB P Findlay
Feb 18, 2005·The New England Journal of Medicine·Nancy E Kemeny, Mithat Gonen
Jun 14, 2005·Cancer Cell·Johanna A Joyce
Jul 19, 2005·Cancer Research·Erik W ThompsonDavid Tarin
Jul 19, 2005·Cancer Research·David TarinDonald F Newgreen
Oct 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven R AlbertsJohn H Donohue
Nov 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Birthe Willipinski-StapelfeldtKlaus Pantel
Jan 7, 2006·Nature Reviews. Cancer·Karin E de VisserLisa M Coussens
May 2, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Nicolas VautheyEddie K Abdalla
Jul 11, 2006·Annual Review of Cell and Developmental Biology·Celeste M Nelson, Mina J Bissell
Aug 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stéphane BenoistBernard Nordlinger
Sep 2, 2006·Clinical Colorectal Cancer·Steven J CohenNeal J Meropol
Sep 7, 2006·Annals of Surgical Oncology·Eddie K AbdallaDavid Mahvi
Nov 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas AloiaRené Adam
Apr 19, 2007·Nature Reviews. Genetics·Don X Nguyen, Joan Massagué
Jan 3, 2008·Cancer Cell·Yves HüsemannChristoph A Klein

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Citations

Feb 11, 2014·Annals of Surgery·Lars Thomas SeebergGro Wiedswang

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